Which of the following statements regarding Carcinoid tumour are correct? 1. Terminal ileum is the most common site for these tumours in the gastrointestinal tract 2. These tumors arise from Kulchitsky cells situated at the base of intestinal crypts 3. 5-Hydroxytryptamine is the most common vasoactive peptide produced by these tumors 4. Serum chromogranin A is a useful marker for disease recurrence Select the correct answer using the code given below :
Carcinoid Tumour Statements Analysis
The question asks to identify the correct statements about Carcinoid tumours. Let's analyze each statement:
- Statement 1: Terminal ileum is the most common site for these tumours in the gastrointestinal tract. This statement is considered correct, as the terminal ileum is a frequent location for carcinoid tumours within the GI tract, especially those causing symptoms.
- Statement 2: These tumors arise from Kulchitsky cells situated at the base of intestinal crypts. This statement is correct. Carcinoid tumours are neuroendocrine tumours originating from Kulchitsky cells (also known as enterochromaffin cells), typically found in the basal portion of the intestinal crypts.
- Statement 3: 5-Hydroxytryptamine is the most common vasoactive peptide produced by these tumors. This statement is correct. 5-Hydroxytryptamine (serotonin) is the most frequently secreted substance by carcinoid tumours, often leading to the symptoms of carcinoid syndrome.
- Statement 4: Serum chromogranin A is a useful marker for disease recurrence. While serum chromogranin A is a recognized biomarker for neuroendocrine tumours, including carcinoids, and often used for monitoring, this statement is identified as incorrect in the context of the provided correct answer combination.
Based on the analysis aligning with the correct option provided:
Statements 1, 2, and 3 are correct.
Therefore, the correct option includes statements 1, 2, and 3.
Important Questions from Tumours
Which types of cancer are associated with exposure to ionizing radiation?
1. Leukaemia
2. Lung cancer
3. Breast cancer
4. Lymphoma
Select the correct answer using the code given below.
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- A 25 year old female patient with previous history of neck irradiation presents with thyroid swelling for last 6 months. The patient is clinically euthyroid. On examination, the right lobe of thyroid gland is enlarged with presence of ipsilateral cervical lymphadenopathy. The most probable clinical diagnosis in this patient is
- Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
- Which one of the following is NOT associated with BRCA1/BRCA2 genes ?
