A. Phosphorylation of mannose residues is a critical step in sorting lysosomal proteins
B. Phosphorylated mannose residues are recognized by a mannose-6-phosphate receptor in the cis Golgi network
C. N-linked glycosylation takes place in both endoplasmic reticulum and Golgi body
D. O-linked glycosylation occurs entirely in Golgi body
Choose the correct answer from the options given below:
Lysosomal Protein Sorting and Glycosylation Steps
This section details the correctness of each statement regarding cellular protein processing.
Statement Analysis
- Statement A: Correct. The phosphorylation of mannose residues on proteins destined for lysosomes creates the mannose-6-phosphate (M6P) tag. This tag acts as a vital sorting signal.
- Statement B: Incorrect. The mannose-6-phosphate receptor (M6PR) recognizes the M6P tag. However, this receptor is primarily located in the trans Golgi network (TGN), not the cis Golgi network. It binds M6P-tagged proteins in the TGN for subsequent delivery to lysosomes.
- Statement C: Correct. N-linked glycosylation begins with the attachment of a core oligosaccharide to asparagine residues in the endoplasmic reticulum (ER). Further processing and modification of this N-linked chain occur in the Golgi body.
- Statement D: Correct. O-linked glycosylation involves the addition of sugars to serine or threonine residues. This process occurs entirely within the compartments of the Golgi body.
Summary of Correct Statements
Statements A, C, and D accurately describe key aspects of protein modification and sorting.
Therefore, the combination of statements A, C, and D is correct.
Similar Questions
- Correct sequence of events in mammalian fertilization:
A. Lysis of zona pellucida by sperm
B. Sperm activated by female reproductive tract
C. Acrosomal reaction
D. Fusion of sperm and egg
E. Sperm binds zona pellucida
Choose the correct answer from the options given below: - Correct sequence of events on larval development of Herdmania:
A. The blastopore of embryo closes and rudiment of tail formed
B. The chorion ruptured due to an enzyme secreted by inner follicle cells
C. The archenteron produces presumptive mesoderm as solid band
D. The presumptive notochordal occupy the central core of larva
E. The fully formed free swimming larva is produced
Choose the correct answer from the options given below: - Choose the correct sequence of enzymes involved in the preparatory phase of glycolysis:
A. Hexokinase
B. Phospho-fructo kinase I
C. Phospho-hexose isomerase
D. Aldolase
E. Triose-phosphate Isomerase
Choose the correct answer from the options given below: - Choose the correct sequence of events on short term endocrine response to stress:
A. Hypothalamus
B. Stressor
C. Sympathetic centers
D. Sympathetic nerve & adrenal medulla
E. Adrenaline & nor-adrenaline response
Choose the correct answer from the options given below: - Choose the correct stages in the development of Gastropods to indicate occurrence of torsion:
A. Pre-torsional stage
B. $90^{\circ}$ lateral anti-clockwise torsion
C. Movement of mantle cavity & anus to the right
D. Larva with ventral flexure in exo-gastric shell
E. $90^{\circ}$ torsion clockwise - Adult stage
Choose the correct answer from the options given below: - Choose the correct sequence of events during a Cardiac cycle:
A. SA (Sino-Atrial) node
B. Atrial depolarization
C. Conduction through AV (Atrio-Ventricular) node
D. Ventricular repolarization
E. Ventricular depolarization
Choose the correct answer from the options given below: - Which of the following statements are correct:
A. In bacteria, RNA primers are removed by the action of polymerase II.
B. In bacteria, polymerase III synthesizes both leading and lagging strands of DNA.
C. In eukaryotes, Polymerases $\delta$ is responsible for synthesis of the lagging strand.
D. In eukaryotes, Polymerases $\varepsilon$ is responsible for synthesis of leading strands.
Choose the correct answer from the options given below: - Which of the following amino acids are encoded by only one codon:
A. Methionine
B. Tyrosine
C. Tryptophan
D. Arginine
Choose the correct answer from the options given below: - Which of the following statements are correct:
A. RNA polymerase I transcribes all ribosomal rRNAs genes
B. RNA polymerase I and III transcribes all ribosomal rRNAs genes
C. RNA polymerase III transcribes genes for tRNAs
D. RNA polymerase III also transcribes microRNAs (miRNAs) and long noncoding RNAs (lncRNAs)
Choose the correct answer from the options given below: - Which of the following statements are correct about poly-A-tail addition to a pre-mRNA:
A. Polyadenylation signals in mammalian cells consist of the hexanucleotide AAUAAA in addition to upstream and downstream (U- or GU-rich) elements
B. Polyadenylation signals in mammalian cells consist of the hexanucleotide GGUAAA in addition to upstream and downstream (U- or GU-rich) elements
C. Poly-A polymerase adds a poly-A tail consisting of about 50 Adenines (A) to the 3' end of the RNA
D. Poly-A polymerase adds a poly-A tail consisting of about 200 Adenines (A) to the 3' end of the RNA
Choose the correct answer from the options given below:
Important Questions from Mixed Topic (CUET PG)
- Who was the founder of Bolshevik Communist party?
- What is the key guide to statecraft in the realist tradition?
- Chronologically arrange the events in the Cold War period.
A. Berlin Wall is constructed
B. Communist China joins the UN
C. Soviet invasion of Czechoslovakia
D. Berlin Blockade
Choose the correct answer from the options given below: Morgenthau's principles of political realism are:
A. Politics is rooted in permanent and unchanging human nature which is basically self centred, self-regarding and self-interested
B. Politics is an autonomous sphere of action and cannot therefore be reduced to morals
C. International Politics is an arena of conflicting self-interests
D. The ethics of international relations is situational ethics which is very different from private morality
Choose the correct answer from the options given below:Who among the following political thinkers consider the anarchical self help system to be a compelling factor for States to maximise their relative power positions?
