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Question

Correct sequence of events in mammalian fertilization:
A. Lysis of zona pellucida by sperm
B. Sperm activated by female reproductive tract
C. Acrosomal reaction
D. Fusion of sperm and egg
E. Sperm binds zona pellucida
Choose the correct answer from the options given below:

This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
B, E, C, A and D

Fertilization Sequence Explained

Understanding the correct sequence of events in mammalian fertilization is crucial. This process involves several key stages from sperm activation to the fusion with the egg.

Key Steps in Fertilization

The chronological order of events is as follows:

  1. Sperm Activation (Capacitation): The sperm must undergo changes within the female reproductive tract to become capable of fertilization. This activation process is termed capacitation. So, the sequence starts with B.
  2. Sperm Binding to Zona Pellucida: Following activation, the sperm travels towards the egg and binds to the outer layer, the zona pellucida. This is represented by E.
  3. Acrosomal Reaction: Upon binding to the zona pellucida, the sperm undergoes the acrosomal reaction. This involves the release of enzymes from the acrosome. This step is C.
  4. Lysis of Zona Pellucida: The enzymes released during the acrosomal reaction digest the zona pellucida, creating a path for the sperm to penetrate. This event is A.
  5. Fusion of Sperm and Egg: Once the zona pellucida is penetrated, the sperm membrane fuses with the egg's plasma membrane, allowing the sperm nucleus to enter the egg. This is the final step, D.

Therefore, the correct sequence of events in mammalian fertilization is B, E, C, A, D.

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