Which of the following is an active form of thyroid hormone that acts through a nuclear receptor to stimulate energy-yielding metabolism by increasing the expression of genes encoding key catabolic enzymes ?
Triidothyroxine (T3)
Understanding Active Thyroid Hormone Function
The question asks to identify the active thyroid hormone responsible for stimulating metabolism through a nuclear receptor pathway. This hormone increases the expression of genes for catabolic enzymes.
Mechanism of Thyroid Hormone Action
Thyroid hormones exert their effects by binding to nuclear receptors, which then modulate gene transcription. This process regulates various metabolic activities.
- Thyroglobulin (Tyr) and Thyroglobulin (Tyr-I) are precursors in thyroid hormone synthesis, not the active hormones themselves.
- Thyroxine (T4) is a major thyroid hormone secreted by the thyroid gland, but it is largely considered a prohormone. It has lower affinity for the thyroid hormone receptor compared to T3.
- Triiodothyroxine (T3) is the principal biologically active thyroid hormone. It has a higher affinity for the nuclear thyroid hormone receptor and is significantly more potent than T4 in regulating cellular metabolism. T3 binds to the receptor, forming a complex that influences gene expression, notably increasing the synthesis of enzymes involved in catabolism and energy production.
Identifying the Active Form
Based on its higher potency and direct action on nuclear receptors to regulate metabolism via gene expression, Triiodothyroxine (T3) is the correct answer.
Similar Questions
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A. Metabolic acidosis decreased plasma bicarbonate
B. Metabolic alkaloses decreased plasma bicarbonate
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D. Respiratory acidosis decreased $pco_{2}$
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Reason (R) : It is because less electrons are shared between atoms in double bonds they require more energy to break than single bonds.
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List - I shows various isotopes and List - II indicates their half-lives.
Match List - I with List - II.
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A. Bradford
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Choose the correct answer from the options given below :
Important Questions from Mixed Topic (CUET PG)
- Who was the founder of Bolshevik Communist party?
- What is the key guide to statecraft in the realist tradition?
- Chronologically arrange the events in the Cold War period.
A. Berlin Wall is constructed
B. Communist China joins the UN
C. Soviet invasion of Czechoslovakia
D. Berlin Blockade
Choose the correct answer from the options given below: Morgenthau's principles of political realism are:
A. Politics is rooted in permanent and unchanging human nature which is basically self centred, self-regarding and self-interested
B. Politics is an autonomous sphere of action and cannot therefore be reduced to morals
C. International Politics is an arena of conflicting self-interests
D. The ethics of international relations is situational ethics which is very different from private morality
Choose the correct answer from the options given below:Who among the following political thinkers consider the anarchical self help system to be a compelling factor for States to maximise their relative power positions?
