1. Valproic acid
2. Lamotrigine
3. Carbamazepine
4. Propranolol
Select the correct answer using the code given below :
Understanding Mood Stabilizers in Bipolar Disorder
Mood stabilizers are drugs used to control the manic and depressive episodes of bipolar disorder without triggering a switch to the opposite pole. The classic mood stabilizers include lithium and several antiepileptic drugs that have demonstrated efficacy in this role. The correct answer is 1, 2 and 3 — Valproic acid, Lamotrigine and Carbamazepine.
Analyzing Each Drug
- 1. Valproic Acid (Sodium Valproate): A well-established anticonvulsant that is one of the first-line mood stabilizers, particularly effective for acute manic and mixed episodes of bipolar disorder.
- 2. Lamotrigine: An anticonvulsant mood stabilizer that is especially useful for the maintenance/prophylactic phase of bipolar disorder, being more effective at preventing depressive relapses than manic relapses.
- 3. Carbamazepine: Another anticonvulsant with proven mood-stabilizing action, used particularly in acute mania and as an alternative or adjunct when lithium or valproate is not tolerated or effective.
- 4. Propranolol: This is a non-selective beta-adrenergic blocker, not a mood stabilizer. It is used for conditions such as hypertension, performance anxiety, essential tremor, and to manage drug-induced akathisia or lithium-induced tremor. It has no established role as a mood-stabilizing agent in bipolar disorder and is therefore excluded from the correct combination.
Conclusion
Since Valproic acid, Lamotrigine, and Carbamazepine are all recognized anticonvulsant mood stabilizers used in bipolar disorder, while Propranolol is a beta-blocker with no mood-stabilizing property, the correct code is 1, 2 and 3.
Important Questions from Bipolar Disorder
Long term treatment of bipolar disorder with lithium carbonate can cause which of the following adverse effects ?
1. Weight loss
2. Hypothyroidism
3. Increased levels of parathyroid hormone
4. Nephrogenic diabetes insipidus
Select the correct answer using the code given below:
Which of the following are classified as mood-stabilising psychotropic drugs?
1. Lithium
2. Valproate
3. Lamotrigine
Select the correct answer using the code given below:
- Lithium carbonate is employed in the following conditions except:
- The mainstay treatment of bipolar disorders is:
Match List I with List II and select the correct answer using the code given below the lists :
List I (Disease) List II (Drug) A. Bipolar disorder 1. Clomipramine B. Major depression 2. Clozapine C. Schizophrenia 3. Venlafaxine D. Obsessive compulsive disorder 4. Lithium Code :
