Histological Grade and Prognosis Correlation
The histological grade of a malignancy assesses how abnormal the cancer cells appear under a microscope and influences the predicted course of the disease (prognosis).
Analyzing Malignancy Prognosis Factors
Different cancers rely on various factors for prognostic assessment. Let's review the options:
- Prostate cancer: Prognosis is influenced by the Gleason score (a grading system) but significantly relies on clinical stage and PSA levels.
- Melanoma: Prognosis is primarily determined by tumor thickness (Breslow depth), ulceration, and mitotic rate rather than a distinct histological grade.
- Colonic adenocarcinoma: While tumor grade (differentiation) is considered, the overall TNM stage is the most critical prognostic factor.
- Soft tissue sarcoma: Histological grade is a primary determinant of prognosis. High-grade sarcomas (e.g., Grade 3) tend to grow faster, metastasize more frequently, and have a poorer prognosis compared to low-grade sarcomas (e.g., Grade 1).
Conclusion on Grading and Prognosis
Among the choices provided, the histological grade shows the strongest correlation with the prognosis specifically in soft tissue sarcomas.
Important Questions from Tumours
Which types of cancer are associated with exposure to ionizing radiation?
1. Leukaemia
2. Lung cancer
3. Breast cancer
4. Lymphoma
Select the correct answer using the code given below.
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- A 25 year old female patient with previous history of neck irradiation presents with thyroid swelling for last 6 months. The patient is clinically euthyroid. On examination, the right lobe of thyroid gland is enlarged with presence of ipsilateral cervical lymphadenopathy. The most probable clinical diagnosis in this patient is
Which of the following statements regarding Carcinoid tumour are correct?
1. Terminal ileum is the most common site for these tumours in the gastrointestinal tract
2. These tumors arise from Kulchitsky cells situated at the base of intestinal crypts
3. 5-Hydroxytryptamine is the most common vasoactive peptide produced by these tumors
4. Serum chromogranin A is a useful marker for disease recurrence
Select the correct answer using the code given below :
- Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
