Genetics: Calculate Heterozygote Frequency
This problem involves calculating the frequency of heterozygotes ($Y/y$) in a population under Hardy-Weinberg equilibrium. The Hardy-Weinberg principle relates allele frequencies to genotype frequencies in a randomly mating population.
Applying Hardy-Weinberg Principle
In a randomly mating population, allele frequencies in the gametes directly reflect the allele frequencies in the population. Let $p$ represent the frequency of the dominant allele ($Y$) and $q$ represent the frequency of the recessive allele ($y$).
- Given frequency of the $Y$ allele (in sperm and egg) is $p = 0.70$.
- Since $p + q = 1$, the frequency of the $y$ allele is $q = 1 - p = 1 - 0.70 = 0.30$.
- The frequency of the $Y/y$ heterozygotes in the population is given by the term $2pq$ in the Hardy-Weinberg equation.
- Calculation: Frequency of $Y/y$ heterozygotes = $2 \times p \times q$
- Frequency of $Y/y$ heterozygotes = $2 \times 0.70 \times 0.30$
- Frequency of $Y/y$ heterozygotes = $2 \times 0.21$
- Frequency of $Y/y$ heterozygotes = $0.42$
Rounding to two decimal places, the frequency of $Y/y$ heterozygotes is $0.42$.
Important Questions from Population Genetics and Epigenetics
Which of the following conditions will contribute to the stability of a gene pool in a natural population?
P. Large population
Q. No net mutation
R. Non-random mating
S. No selection
- An isolated population on an island has the following genotypic frequencies:Assuming that there are only two alleles (A and a) for the gene, the genotypic frequency of AA in the next generation will be ________
Genotype AA Aa aa Frequency 0.3 0.4 0.3 In a genetic study, $80$ people were found to have alleles for polydactyly. Only $36$ of them were polydactylous. What is the extent of penetrance percentage? _______________
- If an unbiased coin is tossed 10 times, the probability that all outcomes are same will be _________ $x10^{-5}$
- Consider a population of $10,000$ individuals, of which $2500$ are homozygotes (PP) and $3000$ are heterozygotes (Pp) genotype. The frequency of allele p in the population is _________.
