Genotype AA Aa aa Frequency 0.3 0.4 0.3
This question relates to population genetics and the Hardy-Weinberg equilibrium principle, which predicts genotype frequencies in the next generation based on current allele frequencies, assuming random mating and no evolutionary influences.
First, determine the frequencies of the alleles 'A' (p) and 'a' (q) from the given genotypic frequencies:
The allele frequency 'p' (frequency of A) is calculated as:
$ p = \text{Frequency(AA)} + \frac{1}{2} \times \text{Frequency(Aa)} $
Substituting the values:
$ p = 0.3 + \frac{1}{2} \times 0.4 = 0.3 + 0.2 = 0.5 $
The allele frequency 'q' (frequency of a) is calculated as:
$ q = \text{Frequency(aa)} + \frac{1}{2} \times \text{Frequency(Aa)} $
Substituting the values:
$ q = 0.3 + \frac{1}{2} \times 0.4 = 0.3 + 0.2 = 0.5 $
Note: Check that p + q = 1. Here, 0.5 + 0.5 = 1, confirming the allele frequencies.
Under Hardy-Weinberg assumptions (including random mating), the genotype frequencies in the next generation are determined by the square of the allele frequencies.
The expected genotypic frequency of AA in the next generation is calculated using the formula:
$ \text{Frequency(AA)}_{\text{next gen}} = p^2 $
Using the calculated allele frequency p = 0.5:
$ \text{Frequency(AA)}_{\text{next gen}} = (0.5)^2 = 0.25 $
Therefore, the genotypic frequency of AA in the next generation is expected to be 0.25.
Which of the following conditions will contribute to the stability of a gene pool in a natural population?
P. Large population
Q. No net mutation
R. Non-random mating
S. No selection
In a genetic study, $80$ people were found to have alleles for polydactyly. Only $36$ of them were polydactylous. What is the extent of penetrance percentage? _______________