In a genetic study, $80$ people were found to have alleles for polydactyly. Only $36$ of them were polydactylous. What is the extent of penetrance percentage? _______________
Understanding Genetic Penetrance Percentage
Penetrance measures how often a gene variant leads to a specific trait. In this genetic study, we calculate the penetrance percentage for polydactyly.
Calculating Penetrance
The penetrance percentage is calculated using the formula:
$ \text{Penetrance Percentage} = \left( \frac{\text{Number of individuals showing the trait}}{\text{Number of individuals with the allele}} \right) \times 100 $
Applying the Formula
Given:
- Number of individuals with alleles for polydactyly = 80
- Number of individuals who were polydactylous (showing the trait) = 36
Substitute the values into the formula:
$ \text{Penetrance Percentage} = \left( \frac{36}{80} \right) \times 100 $
First, calculate the fraction:
$ \frac{36}{80} = 0.45 $
Now, multiply by 100 to get the percentage:
$ 0.45 \times 100 = 45\% $
The penetrance percentage is 45%. This means that 45% of the individuals carrying the allele for polydactyly actually exhibited the trait.
Important Questions from Population Genetics and Epigenetics
Which of the following conditions will contribute to the stability of a gene pool in a natural population?
P. Large population
Q. No net mutation
R. Non-random mating
S. No selection
- In a random mating population, $Y$ and $y$ are dominant and recessive alleles, respectively. If the frequency of $Y$ allele in both sperm and egg is $0.70$, then the frequency of $Y/y$ heterozygotes (rounded off to two decimal places) is ________
- An isolated population on an island has the following genotypic frequencies:Assuming that there are only two alleles (A and a) for the gene, the genotypic frequency of AA in the next generation will be ________
Genotype AA Aa aa Frequency 0.3 0.4 0.3 - If an unbiased coin is tossed 10 times, the probability that all outcomes are same will be _________ $x10^{-5}$
- Consider a population of $10,000$ individuals, of which $2500$ are homozygotes (PP) and $3000$ are heterozygotes (Pp) genotype. The frequency of allele p in the population is _________.
