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Question

Consider a population of $10,000$ individuals, of which $2500$ are homozygotes (PP) and $3000$ are heterozygotes (Pp) genotype. The frequency of allele p in the population is _________.

Problem Analysis: The question asks for the frequency of the allele 'p' in a given population. We are provided with the total population size and the counts for two genotypes: homozygous dominant (PP) and heterozygous (Pp). We need to derive the count for the homozygous recessive genotype (pp) to calculate the allele frequency.

Allele Frequency Calculation Steps

  1. Determine the count of homozygous recessive (pp) individuals:

    • Total population size = Number of PP + Number of Pp + Number of pp
    • Given: Total = 10,000, PP = 2500, Pp = 3000
    • So, $10,000 = 2500 + 3000 + \text{Number of pp}$
    • Number of pp = $10,000 - 2500 - 3000 = 4500$
  2. Calculate the total number of alleles in the population:

    • Each individual has 2 alleles.
    • Total alleles = Total population size $\times$ 2
    • Total alleles = $10,000 \times 2 = 20,000$
  3. Calculate the total number of 'p' alleles:

    • The 'p' allele is present in both heterozygous (Pp) and homozygous recessive (pp) individuals.
    • Each 'Pp' individual contributes one 'p' allele.
    • Each 'pp' individual contributes two 'p' alleles.
    • Number of 'p' alleles = (Number of Pp $\times$ 1) + (Number of pp $\times$ 2)
    • Number of 'p' alleles = ($3000 \times 1$) + ($4500 \times 2$)
    • Number of 'p' alleles = $3000 + 9000 = 12,000$
  4. Calculate the frequency of the 'p' allele:

    • Frequency of 'p' ($q$) = $\frac{\text{Total number of 'p' alleles}}{\text{Total number of alleles}}$
    • $q = \frac{12,000}{20,000}$
    • $q = \frac{12}{20} = \frac{3}{5} = 0.6$

Final Result

The frequency of allele p in the population is calculated to be 0.6.

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Important Questions from Population Genetics and Epigenetics

  1. Which of the following conditions will contribute to the stability of a gene pool in a natural population? 

    P. Large population 

    Q. No net mutation 

    R. Non-random mating 

    S. No selection

  2. In a random mating population, $Y$ and $y$ are dominant and recessive alleles, respectively. If the frequency of $Y$ allele in both sperm and egg is $0.70$, then the frequency of $Y/y$ heterozygotes (rounded off to two decimal places) is ________
  3. An isolated population on an island has the following genotypic frequencies:
    GenotypeAAAaaa
    Frequency0.30.40.3
    Assuming that there are only two alleles (A and a) for the gene, the genotypic frequency of AA in the next generation will be ________
  4. In a genetic study, $80$ people were found to have alleles for polydactyly. Only $36$ of them were polydactylous. What is the extent of penetrance percentage? _______________

  5. If an unbiased coin is tossed 10 times, the probability that all outcomes are same will be _________ $x10^{-5}$
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