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Question

How many rooted and unrooted phylogenetic trees, respectively, are possible with four different sequences?

The correct answer is
15 and 3

Phylogenetic Tree Counting

The number of possible phylogenetic trees varies depending on whether the trees are rooted or unrooted and the number of distinct sequences (taxa), represented by '$n$'.

Unrooted Phylogenetic Trees Formula

For $n$ distinct sequences, the number of possible unrooted binary phylogenetic trees is given by the formula:

$ \text{Number of unrooted trees} = (2n - 5)!! $

This formula is valid for $n \ge 3$. The double factorial $k!!$ involves multiplying integers down to 1 with the same parity as $k$. For instance, $3!! = 3 \times 1$.

Rooted Phylogenetic Trees Formula

For $n$ distinct sequences, the number of possible rooted binary phylogenetic trees is calculated using:

$ \text{Number of rooted trees} = (2n - 3)!! $

This formula applies for $n \ge 2$. It's worth noting that $(2n-3)!! = (2n-3) \times (2n-5)!!$.

Calculating Trees for Four Sequences

We need to calculate the number of rooted and unrooted trees for $n = 4$ different sequences.

  • Unrooted Trees Calculation: Applying the formula $(2n - 5)!!$ with $n=4$: $ (2 \times 4 - 5)!! = (8 - 5)!! = 3!! = 3 \times 1 = 3 $ Thus, there are 3 possible unrooted trees.
  • Rooted Trees Calculation: Applying the formula $(2n - 3)!!$ with $n=4$: $ (2 \times 4 - 3)!! = (8 - 3)!! = 5!! = 5 \times 3 \times 1 = 15 $ Thus, there are 15 possible rooted trees.

The question asks for the number of rooted and unrooted trees, in that specific order (respectively). Therefore, the result is 15 rooted trees and 3 unrooted trees.

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Important Questions from Molecular Structure of Genes and Chromosomes

  1. Consider the following multiple sequence alignment of four DNA sequences.

    $\begin{matrix}A & C & T & A \\ A & C & T & G \\ A & G & T & C \\ A & G & C & T  \end{matrix} $

    Shannon's entropy of the above alignment is ________.

  2. All pseudogenes DO NOT code for a __________.
  3. C-value paradox refers to
  4. The transcription factor X binds a 10 base pair DNA stretch. In the DNA of an organism, X was found to bind at 20 distinct sites. An analysis of these 20 binding sites showed the following distribution:

    Base  Position in the binding site
    12345678910
    A110001624043
    T301901342024
    G420002460122
    C2012011160211

    What is the consensus sequence for the binding site of X?

  5. Which of the following statements are CORRECT when a protein sequence database is searched using the BLAST algorithm?
    P. A larger E-value indicates higher sequence similarity
    Q. E-value < $10^{-10}$ indicates sequence homology
    R. A higher BLAST score indicates higher sequence similarity
    S. E-value > $10^{10}$ indicates sequence homology
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