How many 3-tuples are possible for the following amino acid sequence?
MADCMWDISEASE
Counting Consecutive 3-Tuples in Amino Acid Sequence
A 3-tuple, in this context, refers to a consecutive subsequence of three amino acids within the given sequence.
The provided amino acid sequence is: MADCMWDISEASE
First, determine the total number of amino acids in the sequence. Counting each letter:
- M, A, D, C, M, W, D, I, S, E, A, S, E
- There are 13 amino acids in the sequence. Let this length be $N = 13$.
To find the number of possible 3-tuples, we can list them starting from each possible position:
- MAD
- ADC
- DCM
- CMW
- MWD
- WDI
- DIS
- ISE
- SEA
- EAS
- ASE
Counting these listed 3-tuples, we find there are 11 possible combinations.
Alternatively, the number of k-length subsequences (tuples) in a sequence of length $N$ is given by the formula: $N - k + 1$.
In this case, $N = 13$ and $k = 3$.
Number of 3-tuples = $13 - 3 + 1 = 11$.
Therefore, there are 11 possible 3-tuples.
Important Questions from Molecular Structure of Genes and Chromosomes
Consider the following multiple sequence alignment of four DNA sequences.
$\begin{matrix}A & C & T & A \\ A & C & T & G \\ A & G & T & C \\ A & G & C & T \end{matrix} $
Shannon's entropy of the above alignment is ________.
- All pseudogenes DO NOT code for a __________.
- C-value paradox refers to
The transcription factor X binds a 10 base pair DNA stretch. In the DNA of an organism, X was found to bind at 20 distinct sites. An analysis of these 20 binding sites showed the following distribution:
Base Position in the binding site 1 2 3 4 5 6 7 8 9 10 A 11 0 0 0 16 2 4 0 4 3 T 3 0 19 0 1 3 4 20 2 4 G 4 20 0 0 2 4 6 0 12 2 C 2 0 1 20 1 11 6 0 2 11 What is the consensus sequence for the binding site of X?
- Which of the following statements are CORRECT when a protein sequence database is searched using the BLAST algorithm?
P. A larger E-value indicates higher sequence similarity
Q. E-value < $10^{-10}$ indicates sequence homology
R. A higher BLAST score indicates higher sequence similarity
S. E-value > $10^{10}$ indicates sequence homology
