Renal Transplant Skin Cancer Post-Immunotherapy
Patients undergoing renal transplantation typically require immunosuppressive therapy, often referred to as immunotherapy, to prevent organ rejection. This therapy suppresses the immune system, increasing the risk of various complications, including malignancies.
Among the various risks associated with long-term immunosuppression post-renal transplant, skin cancers become notably more common. The question asks for the most commonly seen skin cancer type.
Common Post-Transplant Skin Cancers
- Immunosuppression impairs the immune system's ability to detect and eliminate abnormal or cancerous cells, including those originating in the skin.
- Factors like viral infections (e.g., Human Papillomavirus - HPV) and chronic sun exposure (UV radiation) are more likely to lead to skin cancer development in this vulnerable population.
- While specific skin cancers like Kaposi's sarcoma or Mycosis Fungoides can occur, the overall category of Skin tumors, particularly non-melanoma skin cancers (like basal cell carcinoma and squamous cell carcinoma), represents the most frequent neoplastic complication affecting the skin.
Therefore, the general classification of Skin tumors is the most accurate answer for the most commonly seen skin cancer in renal transplant patients following immunotherapy.
Important Questions from Tumours
Which types of cancer are associated with exposure to ionizing radiation?
1. Leukaemia
2. Lung cancer
3. Breast cancer
4. Lymphoma
Select the correct answer using the code given below.
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- A 25 year old female patient with previous history of neck irradiation presents with thyroid swelling for last 6 months. The patient is clinically euthyroid. On examination, the right lobe of thyroid gland is enlarged with presence of ipsilateral cervical lymphadenopathy. The most probable clinical diagnosis in this patient is
Which of the following statements regarding Carcinoid tumour are correct?
1. Terminal ileum is the most common site for these tumours in the gastrointestinal tract
2. These tumors arise from Kulchitsky cells situated at the base of intestinal crypts
3. 5-Hydroxytryptamine is the most common vasoactive peptide produced by these tumors
4. Serum chromogranin A is a useful marker for disease recurrence
Select the correct answer using the code given below :
- Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
