Question
First licensed vaccine generated by reverse vaccinology is :
This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
MenB
Identifying the First Reverse Vaccinology Vaccine
The question asks to identify the first licensed vaccine developed using the innovative technique of reverse vaccinology. This method involves sequencing a pathogen's genome to identify potential vaccine targets.
Reverse Vaccinology Explained
Reverse vaccinology represents a modern approach to vaccine development. Instead of relying on traditional methods like culturing pathogens, it uses genomics and bioinformatics to predict and select antigens that are likely to provoke a protective immune response.
Analysis of Vaccine Options
- MenB: The vaccine against serogroup B *Neisseria meningitidis* (MenB) is widely recognized as the first vaccine licensed that utilized reverse vaccinology principles. Its development involved identifying surface proteins through genomic analysis.
- PCV (Pneumococcal Conjugate Vaccine): While a crucial vaccine, PCV development predates the widespread application of reverse vaccinology and relied on different methodologies.
- GBS (Group B Streptococcus): Vaccines for Group B Strep are areas of active research, with reverse vaccinology being explored, but they are not the first licensed vaccine developed this way.
- DPT (Diphtheria, Pertussis, Tetanus): This is a combination vaccine developed using traditional immunological methods long before reverse vaccinology emerged.
Conclusion
Based on the methodology of development, the MenB vaccine is the correct answer as the first licensed vaccine generated through reverse vaccinology.
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