A. Para amino benzoic acid
B. Tetrahydro folate
C. Dihydrofolate
D. DNA
Choose the correct answer from the options given below:
The question deals with the sequence of chemical entities involved in nucleic acid synthesis in bacteria. The correct sequence is: Para amino benzoic acid (PABA) → Dihydrofolate → Tetrahydrofolate → DNA. Let's understand each step involved in this sequence:
- Para Amino Benzoic Acid (PABA): PABA is a precursor for the synthesis of folate in bacteria. Bacteria use PABA to synthesize dihydrofolate, an important folate intermediate.
- Dihydrofolate: This is synthesized from PABA and is the substrate for the enzyme dihydrofolate reductase, which converts it into tetrahydrofolate.
- Tetrahydrofolate: This is the active form of folate, which acts as a coenzyme in the synthesis of nucleic acids. It's involved in transferring one-carbon units in various metabolic reactions, crucial for the synthesis of purines and thymidylate, essential components of nucleic acids.
- DNA: Ultimately, the synthesis of nucleotides leads to the creation of DNA, which is vital for the replication and function of bacterial cells.
Thus, the correct sequence of chemical entities is A (Para amino benzoic acid), C (Dihydrofolate), B (Tetrahydrofolate), D (DNA).
Therefore, the correct answer is: A, C, B, D.
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