Poor prognostic indicators in advanced germ cell tumours show
1. primary sites in mediastinum
2. non-pulmonary metastasis
3. lactate dehydrogenase more than 10 times of normal value
Which of the statements given above are correct?
Prognostic Indicators in Germ Cell Tumours
The question asks to identify the poor prognostic indicators among the given statements for advanced germ cell tumours.
- Statement 1: Primary site in mediastinum - A primary mediastinal location is recognized as a poor prognostic factor for germ cell tumours compared to testicular primary sites.
- Statement 2: Non-pulmonary metastasis - Metastases to sites other than the lungs, such as the brain or liver, often signify advanced disease and are considered adverse prognostic indicators.
- Statement 3: Lactate dehydrogenase (LDH) more than 10 times of normal value - Significantly elevated serum LDH levels (typically >10 times the upper limit of normal) are a strong indicator of high tumour burden and aggressive disease, classifying it as a poor prognostic factor.
Conclusion on Correct Statements
Based on established criteria for assessing germ cell tumours, all three listed factors indicate a poor prognosis.
Therefore, statements 1, 2, and 3 are correct.
Important Questions from Tumours
- Which one of the following is NOT correct regarding MEN-1 syndrome?
- All of the following are hormonal agents used in treatment of cancer EXCEPT:
- Which one of the following is NOT associated with BRCA1/BRCA2 genes ?
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
