A. Recognition by CD4+ T cells
B. Antigen uptake by APC
C. Transport of MHC-peptide complex to cell surface
D. Peptide loading onto MHC class II molecule
E. Fusion of phagosome with lysosome
Choose the correct answer from the options given below :
The question asks to arrange the steps involved in antigen processing via the endocytic pathway in the correct sequence. This pathway is crucial for antigen presentation to CD4+ T cells by Antigen-Presenting Cells (APCs).
Endocytic Pathway Antigen Processing Steps
The correct order of events in antigen processing by the endocytic pathway is as follows:
- B. Antigen uptake by APC: Extracellular antigens are first taken up by the APC through endocytosis (phagocytosis or pinocytosis).
- E. Fusion of phagosome with lysosome: The vesicle containing the antigen (phagosome) fuses with a lysosome. Lysosomal enzymes degrade the antigen into smaller peptides within the phagolysosome.
- D. Peptide loading onto MHC class II molecule: MHC class II molecules, synthesized separately, are directed to the endocytic compartment. Here, the peptides generated from antigen degradation are loaded onto the MHC class II molecules.
- C. Transport of MHC-peptide complex to cell surface: The stable complex of MHC class II bound to a peptide fragment is transported to the plasma membrane of the APC.
- A. Recognition by CD4+ T cells: The MHC class II-peptide complex displayed on the APC surface is then recognized by the T cell receptor (TCR) on a complementary CD4+ T helper cell, initiating an immune response.
Therefore, the correct sequence is B, E, D, C, A.
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Important Questions from Mixed Topic (CUET PG)
- Who was the founder of Bolshevik Communist party?
- What is the key guide to statecraft in the realist tradition?
- Chronologically arrange the events in the Cold War period.
A. Berlin Wall is constructed
B. Communist China joins the UN
C. Soviet invasion of Czechoslovakia
D. Berlin Blockade
Choose the correct answer from the options given below: Morgenthau's principles of political realism are:
A. Politics is rooted in permanent and unchanging human nature which is basically self centred, self-regarding and self-interested
B. Politics is an autonomous sphere of action and cannot therefore be reduced to morals
C. International Politics is an arena of conflicting self-interests
D. The ethics of international relations is situational ethics which is very different from private morality
Choose the correct answer from the options given below:Who among the following political thinkers consider the anarchical self help system to be a compelling factor for States to maximise their relative power positions?
