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Question

A girl child has which of the following combinations of chromosomes in her cells?

This question was previously asked in
RRB ALP 2018 CBT 2 Fitter Question Paper (21-Jan-2019) (Shift 3)
The correct answer is

44 autosomes + XX

Understanding Chromosomes in a Girl Child

Human cells contain a specific number of chromosomes which carry our genetic information. These chromosomes are typically found in pairs within the nucleus of most cells.

Chromosome Types in Humans

Humans have a total of 46 chromosomes in most body cells. These 46 chromosomes can be divided into two main types:

  • Autosomes: These are chromosomes that carry genetic information for traits other than sex determination. Humans have 22 pairs of autosomes. Since they are in pairs, the total number of autosomes is $22 \times 2 = 44$.
  • Sex Chromosomes: These chromosomes determine the biological sex of an individual. Humans have one pair of sex chromosomes. There are two types of sex chromosomes: X and Y.

Sex Chromosome Combinations

The combination of sex chromosomes determines whether a person is biologically male or female:

  • A person with two X chromosomes (XX) is typically female.
  • A person with one X chromosome and one Y chromosome (XY) is typically male.

So, the total number of chromosomes in a typical human cell is 44 autosomes plus the sex chromosomes.

Chromosome Combination for a Girl Child

A girl child is biologically female. As explained above, the sex chromosome combination for a female is XX. Therefore, the complete chromosomal makeup of a girl child's cell is the standard number of autosomes combined with the female sex chromosomes.

Number of autosomes = 44

Sex chromosomes = XX

Total chromosomes = 44 + XX = 46

Thus, a girl child has 44 autosomes and two X chromosomes.

Analyzing the Options for Girl Child Chromosomes

Let's look at the provided options based on our understanding of chromosome combinations in a girl child:

  • Option 1: 44 autosomes + XX - This matches our finding for a girl child, which is 44 autosomes and the XX sex chromosome combination.
  • Option 2: 22 autosomes + XX - This is incorrect. Humans have 22 pairs of autosomes, totaling 44 autosomes, not 22 autosomes.
  • Option 3: 44 autosomes + XY - This combination (44 autosomes + XY) represents the chromosomal makeup of a typical male, not a girl child.
  • Option 4: 22 autosomes + XY - This is incorrect for two reasons: humans have 44 autosomes (not 22), and the XY combination is for a male (not a girl child).

Therefore, the correct combination of chromosomes in a girl child's cells is 44 autosomes + XX.

Chromosome Type Number in Humans In a Girl Child In a Boy Child
Autosomes 44 (22 pairs) 44 44
Sex Chromosomes 2 (1 pair) XX XY
Total Chromosomes 46 44 + XX = 46 44 + XY = 46

Revision Table: Human Chromosome Basics

Term Explanation
Chromosome Structure in cell nucleus carrying genetic information (DNA).
Autosomes Chromosomes (44 in humans) that are not sex chromosomes.
Sex Chromosomes Chromosomes (XX or XY in humans) that determine sex.
Diploid Number ($2n$) Total number of chromosomes in most body cells (46 in humans).
Haploid Number ($n$) Number of chromosomes in gametes (sperm/egg), which is half the diploid number (23 in humans: 22 autosomes + 1 sex chromosome).

Additional Information on Chromosomes and Sex Determination

Sex determination in humans is primarily based on the presence or absence of the Y chromosome. The Y chromosome carries a gene called SRY (Sex-determining Region Y) which triggers the development of male characteristics. In the absence of a Y chromosome (as in XX individuals), female development occurs.

Gametes (sperm and egg cells) have half the number of chromosomes found in body cells. This is the haploid number ($n$).

  • An egg cell always contains 22 autosomes + one X chromosome.
  • A sperm cell contains either 22 autosomes + one X chromosome or 22 autosomes + one Y chromosome.

When an egg (22+X) is fertilized by a sperm (22+X), the resulting zygote is (44+XX), which develops into a girl child. When an egg (22+X) is fertilized by a sperm (22+Y), the resulting zygote is (44+XY), which develops into a boy child.

This process ensures that the offspring inherits the correct number of chromosomes (46) from both parents.

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