Understanding Protein Sequence Motif Databases
The question asks to identify the database specifically designed for storing protein sequence motifs. Motifs are short, conserved patterns in protein sequences that are often associated with specific functions or structures.
Database Analysis
- PROSITE: This database is a curated collection of protein families and domains represented by patterns and profiles. It is explicitly designed to store and search for sequence patterns (motifs) that characterize these protein groups.
- TrEMBL: This is a component of the UniProt Knowledgebase (UniProtKB) that contains a large collection of protein sequences that are not yet fully reviewed. While it holds sequences, it's not primarily a motif database.
- SWISSPROT: Also part of UniProtKB, SWISSPROT contains high-quality, manually annotated protein sequences. It focuses on detailed functional information but isn't specifically a motif pattern database like PROSITE.
- PDB: The Protein Data Bank (PDB) is a repository for the 3D structural data of proteins and nucleic acids. It focuses on structure, not sequence motifs.
Conclusion
Based on the analysis, PROSITE is the specialized database for protein sequence motifs.
Important Questions from Structure and Function of Biomolecules
- An element that is present in a nucleotide but not in a nucleoside is __________.
- Which one of the following coenzymes is utilised by alanine racemase for the conversion of L-Alanine to D-Alanine?
- Which of the following show(s) optical activity at 100 mM concentration in water?
An octapeptide composed of these L-amino acids – Lys, Thr, Ser, Met, Arg, Trp, Tyr, Glu was subjected to analyses with the following outcomes:
P. The N-terminal sequencing analysis by Sanger's method yielded 'Ser' at the N-terminus
Q. Chymotrypsin treatment gave a pentapeptide, a ‘Tyr' containing dipeptide and a free ‘Glu'
R. Cyanogen bromide treatment gave two tetrapeptides
S. Trypsin treatment gave two tripeptides and a dipeptide
Which one of the following is the correct octapeptide sequence?
- Which of the following amino acids contain(s) two chiral carbons?
