1. Incidence has decreased due to rarely combined therapy of axillary LN dissection and
radiotherapy
2. Precipitating cause like LN metastasis is a major determinant
3. The condition is often painful
4. Oedematous limb is susceptible to bacterial infection
Select the correct answer using the code given below:
This solution analyzes the correctness of statements regarding lymphoedema, a potential side effect following breast cancer treatment.
This statement is considered correct. Combining axillary lymph node (LN) dissection with radiotherapy significantly increases lymphoedema risk. As treatments evolve, this aggressive combination is used less frequently, leading to a potential decrease in overall lymphoedema incidence compared to past practices.
This statement is considered incorrect. While lymph node metastasis can be a contributing factor or risk indicator, the primary precipitating causes of lymphoedema *following treatment* are the surgical removal of lymph nodes (axillary LN dissection) and/or radiation therapy, which directly damage the lymphatic system.
This statement is considered correct. Lymphoedema commonly causes symptoms like limb heaviness, aching, discomfort, and pain, alongside visible swelling.
This statement is considered correct. Impaired lymphatic drainage in an oedematous limb creates an environment where bacterial infections, such as cellulitis, are more likely to occur and can be severe.
Based on the analysis, statements 1, 3, and 4 are correct. Statement 2 is incorrect because treatment itself is typically the direct precipitating cause.
The correct combination of statements is 1, 3, and 4.