Breast Cancer Classification
Gene array analysis helps classify breast cancer into distinct molecular subtypes based on gene expression patterns. This classification is crucial for determining prognosis and treatment strategies.
Major Breast Cancer Subtypes via Gene Array
The main subtypes identified through gene expression profiling include:
- Luminal A and Luminal B: Characterized by expression of genes typically found in luminal cells of the breast, often hormone receptor-positive.
- HER2-enriched: Defined by high expression of the HER2 gene.
- Basal-like (Triple Negative): Lacks expression of Estrogen Receptor (ER), Progesterone Receptor (PR), and HER2.
Identifying the Exception
The question asks which option is NOT a major subtype classification derived from gene array analysis. Let's examine the options:
- Luminal A and Luminal B: These are distinct major subtypes identified by gene arrays.
- Triple negative: This represents the Basal-like subtype, a major classification.
- Her-2 receptor positive: This characteristic defines the HER2-enriched subtype, another major classification.
- Oestrogen receptor positive: While being Oestrogen receptor positive (ER-positive) is a key feature defining the Luminal A and Luminal B subtypes, it is not considered a major subtype classification *itself* in the context of gene array analysis results. It's a marker used to define the subtypes rather than a standalone subtype category like Luminal A/B or Triple Negative.
Therefore, Oestrogen receptor positive is the classification that is not typically listed as a primary subtype resulting directly from gene array analysis, unlike the others.
Conclusion
Based on standard gene array analysis classifications, Oestrogen receptor positive status is a characteristic, not a standalone major subtype.
Important Questions from Neck & Breast Surgery
- Medical management of thyrotoxic crisis includes all of the following EXCEPT:
- First line hormone therapy for post-menopausal woman with metastatic carcinoma breast is:
- Which of the following statements regarding lymphoedema following breast cancer treatment are correct?
1. Incidence has decreased due to rarely combined therapy of axillary LN dissection and
radiotherapy
2. Precipitating cause like LN metastasis is a major determinant
3. The condition is often painful
4. Oedematous limb is susceptible to bacterial infection
Select the correct answer using the code given below: - No increased relative risk of invasive breast carcinoma based on histopathological examination of benign breast tissue is for all of the following EXCEPT:
- Which of the following statements regarding Paget's disease of nipple are correct?
1. It represents benign pathology of nipple areola complex
2. It is eczema like condition of nipple and areola
3. Erosion of nipple is seen
4. Nipple biopsy is required for definitive diagnosis
Select the correct answer using the code given below:
