Which of the following is a common cause of physiological jaundice in a newborn?
Immature liver function
Physiological jaundice appears on day 2–3 of life in otherwise healthy newborns and usually fades within 1–2 weeks.
It occurs because the newborn’s liver is immature: the enzyme glucuronyl transferase is low, so unconjugated bilirubin cannot be conjugated and excreted fast enough. At the same time, fetal red cells with a shorter lifespan break down rapidly, raising the bilirubin load.
Genetic disorders and liver infections cause pathological (not physiological) jaundice, and vitamin deficiency is not its usual cause.
Hence, Immature liver function.
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