Which immune system fails to discriminate between self and non-self ?
A. Insulin - dependent diabetes ($\beta$-cell antibodies)
B. Asthama (antibodies against lung cells)
C. Myasthenia gravis (acetyl choline receptor autoantibodies)
D. Hepatitis (antibody against hepatic cells)
E. Rheumatoid arthritis (antibodies against joint protein)
Choose the correct answer from the options given below :
Immune System Failure: Self vs. Non-Self Discrimination
The immune system's primary role is to distinguish between the body's own components (self) and foreign invaders (non-self). When this discrimination fails, the immune system mistakenly attacks the body's own tissues, leading to autoimmune diseases.
Analyzing Autoimmune Conditions
We need to identify the conditions listed where the immune system attacks 'self' components:
- A. Insulin-dependent diabetes: Characterized by antibodies attacking the pancreas's beta cells, which produce insulin. This is a clear failure of self-recognition.
- C. Myasthenia gravis: Involves autoantibodies targeting acetylcholine receptors, crucial for nerve-muscle communication. This is an autoimmune attack on self.
- E. Rheumatoid arthritis: An autoimmune disorder where the immune system attacks proteins and tissues in the joints, causing inflammation and damage. This targets self-components.
Evaluating Other Options
Options B and D are less direct examples or potentially ambiguous in the context of pure autoimmune failure:
- B. Asthma: Primarily an inflammatory and allergic condition of the airways, not typically classified as a direct autoimmune attack on lung cells by antibodies.
- D. Hepatitis: While autoimmune hepatitis exists, the term 'Hepatitis' broadly includes viral causes (non-self). Without specification, it's less definitively an example of self vs. non-self failure compared to A, C, and E.
Conclusion on Immune Discrimination Failure
Conditions A (Insulin-dependent diabetes), C (Myasthenia gravis), and E (Rheumatoid arthritis) clearly represent instances where the immune system fails to discriminate between self and non-self, attacking the body's own tissues.
Similar Questions
- Primary changes in Acid Base disorders are :
A. Metabolic acidosis decreased plasma bicarbonate
B. Metabolic alkaloses decreased plasma bicarbonate
C. Respiratory alkalosis decreased $pco_{2}$
D. Respiratory acidosis decreased $pco_{2}$
Choose the correct answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : A covlent single bonds in biological molecules have energies similar to the energy of the C-C bond in ethane.
Reason (R) : It is because less electrons are shared between atoms in double bonds they require more energy to break than single bonds.
In the light of the above statements, choose the most appropriate answer from the options given below : - A solution is called hypertonic when :
List - I shows various isotopes and List - II indicates their half-lives.
Match List - I with List - II.
List - I List - II A. ${ }^{3}\text{H}$ I. 60 days B. ${ }^{14}\text{C}$ II. 14.5 days C. ${ }^{32}\text{P}$ III. 5700 years D. ${ }^{125}\text{I}$ IV. 12.2 years
Choose the correct answer from the options given below :- Based on the position of Centromere Chromosome can be divided into 4 types :
A. Meta centric : Centromere in the middle
B. Submetacentric : Centromere at the end
C. Telocentric : Terminal Centromere
D. Acrocentric : Centromere is close to middle
Choose the correct answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Neurons are the functional cells in brain. Glial cells are the supporting cells of the brain.
Reason (R) : Astroglia are starshaped neuronal cells.
In the light of the above statements, choose the most appropriate answer from the options given below : - Which of the following are the correct components of PCR reation ?
A. Taq Polymerase
B. Buffer (5X)
C. Primers (F and R)
D. NTPs
E. $\\text{H}_{2}\\text{O}$
Choose the correct answer from the options given below : - List the proteins detection techniques in increasing order of sensitivity :
A. Bradford
B. Biuret
C. Lowry
Choose the correct answer from the options given below : - Match List - I with List - II.
List - I List - II A. ELISA I. Visualization of cells B. RIA II. Proteins identification C. Centrifugation III. Hormone detection D. Microscopy IV. Isolation of organelles
Choose the correct answer from the options given below : - Match List - I with List - II.
List - I List - II A. SDS-PAGE I. DNA B. Agarose gel electrophoresies II. Liquid chromatography C. Native Page III. Non-denatured proteins D. HPLC IV. proteins
Choose the correct answer from the options given below :
Important Questions from Mixed Topic (CUET PG)
- Who was the founder of Bolshevik Communist party?
- What is the key guide to statecraft in the realist tradition?
- Chronologically arrange the events in the Cold War period.
A. Berlin Wall is constructed
B. Communist China joins the UN
C. Soviet invasion of Czechoslovakia
D. Berlin Blockade
Choose the correct answer from the options given below: Morgenthau's principles of political realism are:
A. Politics is rooted in permanent and unchanging human nature which is basically self centred, self-regarding and self-interested
B. Politics is an autonomous sphere of action and cannot therefore be reduced to morals
C. International Politics is an arena of conflicting self-interests
D. The ethics of international relations is situational ethics which is very different from private morality
Choose the correct answer from the options given below:Who among the following political thinkers consider the anarchical self help system to be a compelling factor for States to maximise their relative power positions?
