Match List-I with List-II and select the correct answer using the code given below the lists:
List-I (drug) List-II (complications) A. Cisplatinum 1. Haemorrhagic cystitis B. Adriamycin 2. Pulmonary fibrosis C. Bleomycin 3. Cardiomyopathy D. Cyclophosphamide 4. Tubular necrosis
A-4 B-3 C-2 D-1
Drug-Complication Matching
This question requires matching specific chemotherapy drugs from List-I with their known complications found in List-II.
Key Drug Toxicities
- A. Cisplatinum is known for its nephrotoxicity, specifically causing Tubular necrosis.
- B. Adriamycin (Doxorubicin) is associated with cardiotoxicity, leading to Cardiomyopathy.
- C. Bleomycin is recognized for its pulmonary toxicity, resulting in Pulmonary fibrosis.
- D. Cyclophosphamide commonly causes Haemorrhagic cystitis due to its metabolite acrolein irritating the bladder lining.
Matching the Lists
Based on the known toxicities:
- Cisplatinum (A) matches Tubular necrosis (4).
- Adriamycin (B) matches Cardiomyopathy (3).
- Bleomycin (C) matches Pulmonary fibrosis (2).
- Cyclophosphamide (D) matches Haemorrhagic cystitis (1).
Therefore, the correct matching is A-4, B-3, C-2, D-1.
Correct Option Selection
The correct option is the one that reflects the A-4, B-3, C-2, D-1 matching.
Option 4 provides this exact match: A-4, B-3, C-2, D-1.
Important Questions from Tumours
Which types of cancer are associated with exposure to ionizing radiation?
1. Leukaemia
2. Lung cancer
3. Breast cancer
4. Lymphoma
Select the correct answer using the code given below.
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- A 25 year old female patient with previous history of neck irradiation presents with thyroid swelling for last 6 months. The patient is clinically euthyroid. On examination, the right lobe of thyroid gland is enlarged with presence of ipsilateral cervical lymphadenopathy. The most probable clinical diagnosis in this patient is
Which of the following statements regarding Carcinoid tumour are correct?
1. Terminal ileum is the most common site for these tumours in the gastrointestinal tract
2. These tumors arise from Kulchitsky cells situated at the base of intestinal crypts
3. 5-Hydroxytryptamine is the most common vasoactive peptide produced by these tumors
4. Serum chromogranin A is a useful marker for disease recurrence
Select the correct answer using the code given below :
- Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
