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Question

Let $y(t)$ be a bacterial population whose growth is given by 

      $ \frac{dy}{dt} = \lambda(y + 2) $ 

where $ \lambda $ is the growth rate constant. If $y(0) = 1$ and $y(1) = 4$, then the value of $ \lambda $ is

The correct answer is
In 2

Solving the Bacterial Growth Differential Equation

The problem asks for the growth rate constant $ \lambda $ given the differential equation $ \frac{dy}{dt} = \lambda(y + 2) $ and the conditions $ y(0) = 1 $ and $ y(1) = 4 $. We need to solve this differential equation.

Differential Equation Solution Steps

  1. Separate the variables:

    $ \frac{dy}{y + 2} = \lambda dt $
  2. Integrate both sides:

    $ \int \frac{dy}{y + 2} = \int \lambda dt $ $ \ln|y + 2| = \lambda t + C_1 $ where $ C_1 $ is the constant of integration.
  3. Exponentiate to remove the logarithm:

    $ |y + 2| = e^{\lambda t + C_1} = e^{C_1} e^{\lambda t} $ Let $ C = \pm e^{C_1} $. Since population $ y $ is typically non-negative and $ y+2 $ should be positive in this context, we can write: $ y + 2 = C e^{\lambda t} $ $ y(t) = C e^{\lambda t} - 2 $
  4. Use the initial condition $ y(0) = 1 $ to find $ C $:

    $ 1 = C e^{\lambda(0)} - 2 $ $ 1 = C(1) - 2 $ $ C = 3 $ The equation becomes $ y(t) = 3 e^{\lambda t} - 2 $.
  5. Use the second condition $ y(1) = 4 $ to find $ \lambda $:

    $ 4 = 3 e^{\lambda(1)} - 2 $ $ 4 + 2 = 3 e^{\lambda} $ $ 6 = 3 e^{\lambda} $ $ e^{\lambda} = \frac{6}{3} $ $ e^{\lambda} = 2 $
  6. Solve for $ \lambda $ by taking the natural logarithm:

    $ \lambda = \ln(2) $

The value of $ \lambda $ is $ \ln(2) $. This corresponds to the first option.

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Important Questions from Kinetics of Cell Growth Substrate Utilization and Product Formation

  1. If the rate at which $E. coli$ divides is $0.5 \text{ h}^{-1}$, then its doubling time is _______________ h.

  2. Which of the following factors can affect the growth of a microbial culture in a batch cultivation process?
  3. If the doubling time of a bacterial population is 3 hours, then its average specific growth rate during this period is _________ $h^{-1}$. 

    (Round off to two decimal places)

  4. A microorganism is grown in a batch culture using glucose as a carbon source. The apparent growth yield is $0.5 \frac{\text{g biomass}}{\text{g substrate}}$. The initial concentrations of biomass and substrate are $2 \text{ g L}^{-1}$ and $200 \text{ g L}^{-1}$, respectively. Assuming that there is no endogenous metabolism, the maximum biomass concentration that can be achieved is ________ $\text{g L}^{-1}$.
  5. Which one of the following represents non-growth associated product formation kinetics in a bioprocess system? X and P denote viable cell and product concentrations, respectively.
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