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Question

Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Rifampicin is used to treat various bacterial infections particularly tuberculosis.
Reason (R) : It acts by disrupting the bacterial cell-wall, nuclear membrane and mitochondria.
In the light of the above statements, choose the most appropriate answer from the options given below :

This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
(A) is correct but (R) is not correct

Analyzing Assertion (A): Rifampicin Use

Assertion (A) states that Rifampicin is used for bacterial infections, especially tuberculosis (TB). This is medically accurate. Rifampicin is a primary antibiotic used in the treatment regimens for tuberculosis and other bacterial infections like leprosy and meningitis prophylaxis.

Evaluating Reason (R): Rifampicin's Action

Reason (R) claims Rifampicin disrupts the bacterial cell wall, nuclear membrane, and mitochondria. This statement is incorrect:

  • Rifampicin's primary mechanism is inhibiting bacterial DNA-dependent RNA polymerase, stopping transcription.
  • It does not target the bacterial cell wall (unlike penicillins).
  • Bacteria lack a nuclear membrane; they have a nucleoid region.
  • Bacteria do not possess mitochondria; this organelle is found in eukaryotic cells.

Therefore, the stated reason for Rifampicin's effectiveness is factually wrong.

Determining the Correct Option

Based on the analysis:

  • Assertion (A) is correct.
  • Reason (R) is incorrect.

This corresponds to the option stating that (A) is correct, but (R) is not correct.

Conclusion

The most appropriate answer is that Assertion (A) is correct, but Reason (R) is incorrect.

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  1. Who was the founder of Bolshevik Communist party?
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  5. Who among the following political thinkers consider the anarchical self help system to be a compelling factor for States to maximise their relative power positions?

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