Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : In a zinc finger about-30 amino acids form an elongated loop held together at the base by a single $\text{Zn}^{2+}$ ion which is coordinated to form residues (with Cys and/or His)
Reason (R) : The Zn does not itself interact with DNA, rather the coordination of Zn with amino acid residues stabilizes the small structural motif.
In the light of the above statements, choose the most appropriate answer from the options given below :
Zinc Finger Structure and Function Explained
Assertion (A) Analysis
Assertion (A) accurately describes the fundamental structure of a zinc finger. These protein motifs are characterized by a specific arrangement where roughly 30 amino acid residues form a loop. This loop is held together and stabilized by a single zinc ion ($\text{Zn}^{2+}$). The zinc ion achieves this by coordinating with specific amino acid side chains, typically involving cysteine (Cys) and sometimes histidine (His) residues.
Reason (R) Analysis
Reason (R) correctly elucidates the role of the zinc ion. The $\text{Zn}^{2+}$ ion's primary function is not to directly interact with DNA. Instead, it serves a crucial structural purpose. By coordinating with the amino acid residues within the protein sequence, the zinc ion stabilizes the small, specific three-dimensional structural motif (the zinc finger) that allows the protein to correctly position its DNA-binding surfaces.
Relationship Between Assertion and Reason
Reason (R) provides the essential explanation for why the structure described in Assertion (A) is functionally relevant. The stabilization effect of the $\text{Zn}^{2+}$ ion, as detailed in (R), is what allows the ~30 amino acid loop structure mentioned in (A) to form and maintain its conformation. This stabilized structure is critical for the zinc finger's ability to interact with DNA or RNA.
Conclusion
Both Assertion (A) and Reason (R) are factually correct statements regarding zinc finger proteins. Furthermore, Reason (R) explains the functional significance of the structural features described in Assertion (A), confirming that the stabilization by the zinc ion is key to the motif's existence and function.
Similar Questions
- Primary changes in Acid Base disorders are :
A. Metabolic acidosis decreased plasma bicarbonate
B. Metabolic alkaloses decreased plasma bicarbonate
C. Respiratory alkalosis decreased $pco_{2}$
D. Respiratory acidosis decreased $pco_{2}$
Choose the correct answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : A covlent single bonds in biological molecules have energies similar to the energy of the C-C bond in ethane.
Reason (R) : It is because less electrons are shared between atoms in double bonds they require more energy to break than single bonds.
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List - I shows various isotopes and List - II indicates their half-lives.
Match List - I with List - II.
List - I List - II A. ${ }^{3}\text{H}$ I. 60 days B. ${ }^{14}\text{C}$ II. 14.5 days C. ${ }^{32}\text{P}$ III. 5700 years D. ${ }^{125}\text{I}$ IV. 12.2 years
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A. Taq Polymerase
B. Buffer (5X)
C. Primers (F and R)
D. NTPs
E. $\\text{H}_{2}\\text{O}$
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A. Bradford
B. Biuret
C. Lowry
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Choose the correct answer from the options given below : - Match List - I with List - II.
List - I List - II A. SDS-PAGE I. DNA B. Agarose gel electrophoresies II. Liquid chromatography C. Native Page III. Non-denatured proteins D. HPLC IV. proteins
Choose the correct answer from the options given below :
Important Questions from Mixed Topic (CUET PG)
- Who was the founder of Bolshevik Communist party?
- What is the key guide to statecraft in the realist tradition?
- Chronologically arrange the events in the Cold War period.
A. Berlin Wall is constructed
B. Communist China joins the UN
C. Soviet invasion of Czechoslovakia
D. Berlin Blockade
Choose the correct answer from the options given below: Morgenthau's principles of political realism are:
A. Politics is rooted in permanent and unchanging human nature which is basically self centred, self-regarding and self-interested
B. Politics is an autonomous sphere of action and cannot therefore be reduced to morals
C. International Politics is an arena of conflicting self-interests
D. The ethics of international relations is situational ethics which is very different from private morality
Choose the correct answer from the options given below:Who among the following political thinkers consider the anarchical self help system to be a compelling factor for States to maximise their relative power positions?
