Assertion (A) : IgG is the first immunoglobulin produced during a primary immune response.
Reason (R) : IgM has a pentameric structure that allows efficient activation of the complement system.
In the light of the above statements, choose the most appropriate answer from the options given below :
Understanding Immunoglobulin Production
The primary immune response is initiated by the production of specific antibodies. Initially, B cells differentiate and produce predominantly IgM antibodies. This occurs because the gene segments encoding IgM are typically expressed before those encoding IgG.
Assertion (A) states that IgG is the first immunoglobulin produced. This is incorrect, as IgM precedes IgG in the primary response. IgG becomes the dominant antibody later in the primary response and is the main antibody in secondary responses.
Reasoning Behind Complement Activation
Reason (R) focuses on the structure and function of IgM. IgM molecules typically exist as a pentamer, meaning five individual IgM units are linked together. This large, pentameric structure contains multiple binding sites for complement components.
Specifically, the pentameric form of IgM is highly efficient at binding the C1q component of the complement system. This facilitates the rapid and effective activation of the classical complement pathway, leading to pathogen lysis and inflammation.
Therefore, the statement that IgM's pentameric structure allows efficient complement activation is correct.
Similar Questions
- Blue-white screening is based on the activity of :
- Which of the following is not a feature of RNA ?
- RNAi mediated RNA interference mediates which of the following ?
- Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Some microorganisms can use nitrate as a terminal electron acceptor under anaerobic conditions.
Reason (R) : Nitrate can be fully reduced to ammonia in the process of denitrification.
In the light of the above statements, choose the most appropriate answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : A cDNA library contains only expressed genes.
Reason (R) : A cDNA library is made from the mRNA molecules of a cell population.
In the light of the above statements, choose the most appropriate answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Electrophoretic procedures are generally not used to purify proteins.
Reason (R) : Electrophoresis is an analytical method.
In the light of the above statements, choose the most appropriate answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : E.coli is widely used as a host in RDT.
Reason (R) : E.coli grows rapidly and its genetics are well understood.
In the light of the above statements, choose the most appropriate answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Biodiversity is normally greater in the lower latitudes as compared to the higher latitudes.
Reason (R) : Along the mountain gradients, biodiversity is normally greater in the lower altitudes as compared to the higher altitudes.
In the light of the above statements, choose the most appropriate answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Ruminants are able to digest complex plant material.
Reason (R) : The Rumen community contains a community of microorganisms producing a variety of enzymes that can degrade plant polymers.
In the light of the above statements, choose the most appropriate answer from the options given below : - Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : The closer two loci reside along the axis of the chromosome, the more likely they are to be inherited together.
Reason (R) : The farther apart two linked loci, the more likely a random crossover event will occur in between them.
In the light of the above statements, choose the most appropriate answer from the options given below :
Important Questions from Mixed Topic (CUET PG)
- Kalpsutra, the illustrated canonical text is from:-
- The Harappan city almost exclusively devoted to craft production was-:
- Mohandas Karamchand Gandhi launched quit India movement after the failure of:-
- The "Objectives Resolution" was introduced in constituent assembly by:-
- Who among the following was not a member of the constituent assembly:-
