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Question

Fever with splenomegaly and lymphadenopathy can be seen in

The correct answer is
Both infectious mononucleosis and chronic leukaemia

Fever, Splenomegaly, Lymphadenopathy Causes

The question asks to identify the condition(s) associated with fever, splenomegaly (enlarged spleen), and lymphadenopathy (enlarged lymph nodes).

Infectious Mononucleosis Symptoms

Infectious mononucleosis, often caused by the Epstein-Barr virus (EBV), classically presents with:

  • Fever
  • Significant lymphadenopathy (especially cervical)
  • Splenomegaly
  • Fatigue
  • Pharyngitis

Therefore, infectious mononucleosis can exhibit all the mentioned symptoms.

Chronic Leukaemia Symptoms

Chronic leukaemias, such as chronic lymphocytic leukaemia (CLL) or chronic myeloid leukaemia (CML), are cancers of the blood and bone marrow. Symptoms can develop gradually and may include:

  • Fever
  • Enlarged lymph nodes (lymphadenopathy)
  • Enlarged spleen (splenomegaly)
  • Fatigue
  • Night sweats
  • Weight loss

Thus, chronic leukaemia can also present with fever, splenomegaly, and lymphadenopathy.

Conclusion on Symptoms

Since both infectious mononucleosis and chronic leukaemia can manifest with fever, splenomegaly, and lymphadenopathy, the correct choice includes both conditions.

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Important Questions from Viral Infections

  1. A 'slapped cheek' rash is characteristically seen in which of the following infections?
  2. HIV-associated neurocognitive disorder (HAND) includes which of the following? 

    1. Asymptomatic neurocognitive disorder 

    2. Minor neurocognitive disorder 

    3. HIV-associated dementia 

    Select the correct answer using the code given below.

  3. Which of the following treatments for a pregnant lady who has been exposed to a patient of chicken pox are correct? 

    1. Varicella-zoster immune globulin 

    2. Varicella-zoster vaccine 

    3. Acyclovir 

    4. Prednisolone 

    Select the correct answer using the code given below.

  4. Which of the following statements are correct regarding Kyasanur forest disease? 

    1. It is commonly seen in North-Eastern States of India. 

    2. Monkeys act as reservoir of the disease. 

    3. Transmission happens through tick bite. 

    4. Inactivated vaccine is available for its prevention. 

    Select the correct answer using the code given below.

  5. Which one of the following has the highest risk of human immunodeficiency virus (HIV) transmission after single exposure to an HIV-infected source ?
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