Question
Choose the correct sequence of events involved in the synthesis of a secretory protein:
A. Signal peptide binds to the interior of the translocon
B. As the signal sequence emerges from the ribosome, it binds to the SRP
C. The SRP-ribosome complex then binds to an SRP receptor situated within the ER membrane
D. Synthesis of the polypeptide begins on a free ribosome
E. After the nascent polypeptide passes into the lumen of the ER, the signal peptide is cleaved by a membrane protein
Choose the correct answer from the options given below:
This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
D, B, C, A and E
Secretory Protein Synthesis Pathway
The synthesis of secretory proteins involves their targeting to the Endoplasmic Reticulum (ER) for further processing and export. This process follows a specific sequence of events initiated during translation.
Step-by-Step Synthesis Sequence
- Initial Synthesis: The process begins with the synthesis of the polypeptide chain on a free ribosome in the cytoplasm.
Event: D. Synthesis of the polypeptide begins on a free ribosome - Signal Sequence Recognition: As the N-terminal signal sequence emerges from the ribosome, it is recognized and bound by the Signal Recognition Particle (SRP).
Event: B. As the signal sequence emerges from the ribosome, it binds to the SRP - ER Docking: The SRP-ribosome complex, now paused in translation, moves to the ER membrane and binds to an SRP receptor.
Event: C. The SRP-ribosome complex then binds to an SRP receptor situated within the ER membrane - Translocon Insertion: Following docking, the ribosome associates with a protein channel called the translocon. The signal peptide interacts with the translocon, initiating the threading of the nascent polypeptide into the ER lumen.
Event: A. Signal peptide binds to the interior of the translocon - Signal Peptide Cleavage and Completion: Once the polypeptide chain has been fully translocated into the ER lumen, the signal peptide is typically cleaved off by a signal peptidase enzyme embedded in the ER membrane. Translation is completed, and the protein folding and modification process begins within the ER.
Event: E. After the nascent polypeptide passes into the lumen of the ER, the signal peptide is cleaved by a membrane protein
Therefore, the correct sequence is D, B, C, A, E.
Was this answer helpful?
Similar Questions
- Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A): The transcripts of RNA polymerases I and III are not processed.
Reason (R): RNA polymerases I and III lack a C-terminal domain (CTD).
In the light of the above statements, choose the most appropriate answer from the options given below: - Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A): Isoelectric focusing (IEF) is a highly sensitive analytical technique and is particularly useful for studying micro-heterogeneity in a protein.
Reason (R): A protein may show a single band on SDS gel, but may show three bands on an IEF gel. The method is particularly useful for separating isoenzymes, which are same forms of the different enzyme.
In the light of the above statements, choose the most appropriate answer from the options given below: - Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A): It is well known that lack of insulin or thyroid hormone increases the blood cholesterol concentration, whereas excess thyroid hormone decreases the concentration.
Reason (R): These effects are probably caused by changes in the degree of activation of specific enzymes responsible for the metabolism of lipid substances.
In the light of the above statements, choose the most appropriate answer from the options given below: - Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A): The molecular evidences suggest that the sister group of sponges is not choanoflagellates, but mesomycetozoa, a group of parasitic protists. So, can this hypothesis be correct given that these parasites lack collar cells?
Reason (R): The collar cells of sponges bear a significant resemblance to a choanoflagellate cell suggesting that the last common ancestor of animals and their protist sister group might have resembled a choanoflagellate. In this regard, mesomycetozoans could still be sister group of animals. The lack of collar cells in mesomycetozoans would indicate that over the time, their structure evolved in a way that it no longer resembled a choanoflagellate cell pointing out to convergent evolution.
In the light of the above statements, choose the most appropriate answer from the options given below: - True statements about collagen:
A. It is a triple-stranded helical structure, made up of three collagen polypeptide chains, called 'alpha ($\alpha$) chain'
B. It is a repeating tripeptide of Gly-X-Y, where X is often proline, and Y is often 4-hydroxyproline
C. '$\alpha$ chains' are right-handed helix
D. Its glycine residues permit the sharp twisting of the collagen helix
E. Ascorbic acid is required for proline hydroxylation
Choose the correct answer from the options given below: - Choose the correct sequence of events involved in receptor-mediated endocytosis of transferrin:
A. The high pH in the endosome induces transferrin to release its bound iron
B. The low pH in the endosome induces transferrin to completely release its bound iron
C. Iron free transferrin is degraded in lysosome
D. Cell-surface transferrin receptors deliver transferrin with its bound iron to early endosomes by receptor-mediated endocytosis
E. Transferrin receptor along with iron free transferrin is recycled back to the plasma membrane
Choose the correct answer from the options given below: - Correctly arrange the below given Transcription Factors (TFs) as per their involvement in initiation of eukaryotic transcription
A. TFIIB
B. TFIID
C. TFIIE
D. TFIIF
E. TFIIH
Choose the correct answer from the options given below: - Correct sequence of events in cytosolic pathway of antigen presentation:
A. Calnexin dissociates, thereafter class I molecule associates with the chaperone calreticulin and with tapasin
B. Peptides are transported to RER (Rough Endoplasmic Reticulum) via TAP (Transport Associated Protein)
C. Endogenous antigen is degraded by proteasome in cytosol
D. Class I MHC $\alpha$ chain binds calnexin, then $\beta$2 macroglobulin
E. MHC captures peptide and chaperones dissociate
Choose the correct answer from the options given below: - Correct sequence of embryonic developmental stages:
A. Blastula
B. Neurula
C. Morula
D. Fertilized egg
E. Gastrula
Choose the correct answer from the options given below: - The ecological niches are characterized into different axes except one:
Important Questions from Mixed Topic (CUET PG)
- Who was the founder of Bolshevik Communist party?
- What is the key guide to statecraft in the realist tradition?
- Chronologically arrange the events in the Cold War period.
A. Berlin Wall is constructed
B. Communist China joins the UN
C. Soviet invasion of Czechoslovakia
D. Berlin Blockade
Choose the correct answer from the options given below: Morgenthau's principles of political realism are:
A. Politics is rooted in permanent and unchanging human nature which is basically self centred, self-regarding and self-interested
B. Politics is an autonomous sphere of action and cannot therefore be reduced to morals
C. International Politics is an arena of conflicting self-interests
D. The ethics of international relations is situational ethics which is very different from private morality
Choose the correct answer from the options given below:Who among the following political thinkers consider the anarchical self help system to be a compelling factor for States to maximise their relative power positions?
Need Expert Advice?
Upcoming Exams
GATE
February 06, 2027
Test Series
CUET
CUET PG Psychology (HUQP20) 2026 Mock Test Series
10 Tests
753 Attempts
3.7(14)
English
More Questions from CUET PG
