Question
Amino acid residue which is most likely to be found in the interior of water-soluble globular proteins is
The correct answer is
Valine
Protein Interior Amino Acid Identification
The interior of water-soluble globular proteins is shielded from the aqueous environment. This non-polar, hydrophobic environment favors the burial of hydrophobic amino acid residues to minimize unfavorable interactions with water.
Analysis of Amino Acid Residues
We need to identify the most hydrophobic amino acid among the options:
- Threonine: A polar, uncharged amino acid. Tends to be found on the surface.
- Aspartic acid: An acidic, charged amino acid. Found on the surface.
- Valine: A nonpolar, aliphatic amino acid. Highly hydrophobic.
- Histidine: A polar amino acid, which can be uncharged or positively charged depending on the pH. Tends to be found on the surface or in active sites.
Conclusion on Residue Location
Valine, being a strongly hydrophobic residue, is the most likely to be found in the protein's interior, away from the surrounding water.
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Important Questions from Structure and Function of Biomolecules
- Match the carbohydrates in Column I with the correct glycosidic linkages involved in Column II.
Column I Column II P. Amylose 1. $\beta$ ($1\to 4$) Q. Sucrose 2. $\alpha$ ($1\to 4$) R. Amylopectin 3. $\alpha 1\to \beta 2$ S. Cellulose 4. $\alpha$ ($1\to 4$), $\alpha$ ($1\to 6$) - Match the biomolecules in Column I with their function given in Column II
Column I Column II P. Lectins 1. Acts as ATP dependent pump to efflux out small molecules Q. P-glycoprotein 2. Targets lysosomal enzymes to their destination R. Digitoxigenin 3. Specific carbohydrate binding proteins S. Mannose 6-phosphate 4. Inhibits Na$^+$-K$^+$ pump - Which one of the following coenzymes is utilised by alanine racemase for the conversion of L-Alanine to D-Alanine?
- Correctly match the following Monosaccharides with their respective Epimers.
Monosaccharide Epimer P. D-mannose 1. C-3 epimer of D-glucose Q. D-allose 2. C-4 epimer of D-glucose R. D-galactose 3. C-4 epimer of D-mannose S. D-talose 4. C-2 epimer of D-glucose 5. C-5 epimer of D-glucose - Which of the following show(s) optical activity at 100 mM concentration in water?
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