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Question

A young male presented with recent onset urethral discharge and dysuria. On examination, the discharge was profuse and purulent. Microscopy of smears from the discharge revealed Gram-negative diplococci. What is the likely diagnosis?

The correct answer is
Gonorrhoea

Key Clinical Presentation

The patient presents with acute symptoms including urethral discharge and dysuria (painful urination).

The discharge is noted to be profuse and purulent.

Diagnostic Microscopic Findings

Microscopy of the urethral discharge reveals the presence of $\text{Gram-negative diplococci}$. This finding is highly specific for certain bacterial infections.

Differential Diagnosis Evaluation

  • Gonorrhoea: Caused by Neisseria gonorrhoeae, this bacterium is classically identified as Gram-negative diplococci and is a common cause of purulent urethritis with symptoms like discharge and dysuria.
  • Genital Herpes: This is a viral infection. It typically presents with vesicles or ulcers, not profuse purulent discharge with Gram-negative diplococci.
  • Chlamydia: While a common cause of urethritis and discharge, Chlamydia trachomatis are obligate intracellular bacteria and are not seen as Gram-negative diplococci on Gram stains.
  • Syphilis: Caused by Treponema pallidum (a spirochete), syphilis usually presents with a primary chancre, not primarily purulent urethral discharge.

Conclusion

Given the characteristic symptoms (profuse purulent urethral discharge, dysuria) and the definitive microscopic finding of $\text{Gram-negative diplococci}$, Gonorrhoea is the most likely diagnosis.

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Important Questions from Bacterial Infections

  1. Which of the following are major criteria under the Jones Criteria for Acute Rheumatic Fever? 

    1. Chorea 

    2. Erythema Marginatum 

    3. Subcutaneous Nodules 

    4. Polyarthralgia 

    Select the correct answer using the code given below:

  2. Whipple's disease is characterized by the infiltration of small intestinal mucosa by 'foamy' macrophages. Which one of the following histological stains is characteristically used to stain them?
  3. Cat-scratch disease is caused by infection of which of the following organisms?
  4. Which of the following drugs is/are useful in the treatment of Listeria monocytogenes infection? 

    1. Ceftriaxone 

    2. Gentamicin 

    3. Ampicillin 

    4. Sulfamethoxazole 

    Select the correct answer using the code given below.

  5. Which of the following statements are correct regarding brucellosis? 

    1. Fever may develop into an undulating pattern that persists for weeks. 

    2. Associated musculoskeletal symptoms are a feature of the disease. 

    3. Brucellae behave as facultative intracellular parasites. 

    Select the correct answer using the code given below.

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