Chronic Obstructive Pulmonary Disease (COPD) severity, specifically airflow obstruction, is classified using the Global Initiative for Chronic Lung Disease (GOLD) guidelines. This classification primarily relies on the post-bronchodilator Forced Expiratory Volume in 1 second ($FEV_1$) as a percentage of the predicted value.
The GOLD criteria define the following stages:
The condition $FEV_1/FVC < 0.7$ confirms the presence of airflow obstruction, but the severity level is determined by the $FEV_1$ percentage.
In this case, the patient's post-bronchodilator $FEV_1$ is $42\%$ of the predicted value.
Comparing this value to the GOLD criteria:
Therefore, the patient's $FEV_1$ falls within the range for GOLD 3 (Severe) airflow obstruction.
Which of the following are the physiological abnormalities in chronic obstructive lung disease?
1. Reduced total lung capacity(TLC)
2. Increased functional residual capacity
3. Increased residual volume(RV)
4. Increased RV/TLC ratio
Select the correct answer using the code given below: