With regard to management of hypothyroidism, consider the following statements: 1. Treatment is with levothyroxine replacement. 2. It is taken as a single daily dose. 3. Average dose is 1.6 $\mu$gm/kg/day. 4. Full dose per weight should be started in those with coronary artery disease. Which of the statements given above are correct?
Hypothyroidism Management Statement Analysis
This question requires evaluating the correctness of four statements regarding the management of hypothyroidism, specifically focusing on levothyroxine treatment.
Statement 1: Levothyroxine Replacement Therapy
Statement: Treatment is with levothyroxine replacement.
Analysis: This is correct. Levothyroxine, a synthetic form of thyroxine (T4), is the standard and primary treatment for hypothyroidism, aiming to restore normal thyroid hormone levels.
Statement 2: Dosing Frequency
Statement: It is taken as a single daily dose.
Analysis: This is generally correct. Levothyroxine is typically prescribed as a single daily dose, usually taken in the morning on an empty stomach to ensure optimal absorption and consistent hormone levels.
Statement 3: Average Levothyroxine Dose
Statement: Average dose is 1.6 $\mu$gm/kg/day.
Analysis: This is correct. The average starting dose for levothyroxine replacement therapy in adults is approximately 1.6 $\\ \\mu$gm/kg/day. Dosage is adjusted based on individual patient factors and thyroid hormone levels.
Statement 4: Starting Dose in Coronary Artery Disease
Statement: Full dose per weight should be started in those with coronary artery disease.
Analysis: This is incorrect. Patients with known coronary artery disease (CAD) require careful management. Starting levothyroxine at a full replacement dose can increase cardiac workload and potentially precipitate angina or arrhythmias. Therefore, it's recommended to start with a lower dose (e.g., 12.5-25 $\\ \\mu$gm/day) and increase it gradually while monitoring cardiac function.
Conclusion: Correct Statements
Based on the analysis, statements 1, 2, and 3 are correct. Statement 4 is incorrect.
Therefore, the correct option includes statements 1, 2, and 3.
Important Questions from Thyroid Disorders
- Which one of the following diseases is characterized by destructive lymphoid infiltration of the thyroid gland leading to fibrosis and enlargement of the thyroid gland with an increased risk of developing thyroid lymphoma?
With regards to treatment of thyrotoxicosis of Grave's disease, consider the following statements:
1. Propylthiouracil is suitable in breastfeeding patients.
2. Large goitre is an indication for thyroidectomy.
3. Radioiodine is recommended for management in pregnancy.
4. Agranulocytosis is a complication associated with carbimazole.
Which of the statements given above are correct?
- Low serum thyroglobulin levels are seen in
- A 27-year lady underwent thyroidectomy for thyroid carcinoma. Post-operatively she started developing muscle cramps, perioral and peripheral paresthesia, and carpopedal spasm. Which one of the following interventions will be appropriate for this patient?
- Iodine has complex effects on thyroid function. Very high concentrations of iodine inhibit thyroid hormone synthesis and release. This effect is known as
