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Question

A 27-year lady underwent thyroidectomy for thyroid carcinoma. Post-operatively she started developing muscle cramps, perioral and peripheral paresthesia, and carpopedal spasm. Which one of the following interventions will be appropriate for this patient?

The correct answer is
Measure of serum ionized calcium and to administer IV calcium gluconate

The patient is experiencing symptoms such as muscle cramps, perioral and peripheral paresthesia, and carpopedal spasm post-thyroidectomy. These symptoms are indicative of hypocalcemia (low calcium levels in the blood), which is a common complication after thyroidectomy due to potential damage to or removal of the parathyroid glands.

Explanation of Options

  1. Nerve conduction velocity in both upper and lower limbs and to administer methylcobalamin: This approach involves neurological testing and administration of vitamin B12. However, the symptoms presented are more consistent with hypocalcemia rather than a neurological deficiency.
  2. EMG of both lower limbs and to administer oral prednisolone: This approach suggests investigating for a neuromuscular disorder and administering steroids. These actions are not relevant for treating acute hypocalcemia and would not address the immediate symptoms.
  3. Measure of serum ionized calcium and to administer IV calcium gluconate: This is the correct option. The measurement of serum ionized calcium will confirm hypocalcemia, and IV calcium gluconate is used to quickly restore calcium levels and alleviate the symptoms.
  4. Measure of serum bicarbonate and to administer IV bicarbonate: This approach addresses metabolic acidosis, which is not the situation indicated by the symptoms.

Correct Intervention

The correct intervention involves measuring serum ionized calcium and administering IV calcium gluconate to manage hypocalcemia. Here’s why this is the appropriate course of treatment:

  1. Measure of Serum Ionized Calcium: Hypocalcemia needs to be confirmed through a blood test that measures ionized calcium, the biologically active form of calcium, to establish the diagnosis.
  2. Administer IV Calcium Gluconate: This is a rapid treatment for acute hypocalcemia to quickly raise blood calcium levels and relieve symptoms such as muscle cramps and spasms.

Conclusion

The most appropriate treatment option for the symptoms presented post-thyroidectomy is to measure serum ionized calcium and administer IV calcium gluconate. This addresses the underlying issue of hypocalcemia directly and expediently.

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Important Questions from Thyroid Disorders

  1. Which one of the following diseases is characterized by destructive lymphoid infiltration of the thyroid gland leading to fibrosis and enlargement of the thyroid gland with an increased risk of developing thyroid lymphoma?
  2. With regards to treatment of thyrotoxicosis of Grave's disease, consider the following statements: 

    1. Propylthiouracil is suitable in breastfeeding patients. 

    2. Large goitre is an indication for thyroidectomy. 

    3. Radioiodine is recommended for management in pregnancy. 

    4. Agranulocytosis is a complication associated with carbimazole. 

    Which of the statements given above are correct?

  3. With regard to management of hypothyroidism, consider the following statements: 

    1. Treatment is with levothyroxine replacement. 

    2. It is taken as a single daily dose. 

    3. Average dose is 1.6 $\mu$gm/kg/day. 

    4. Full dose per weight should be started in those with coronary artery disease. 

    Which of the statements given above are correct?

  4. Low serum thyroglobulin levels are seen in
  5. Iodine has complex effects on thyroid function. Very high concentrations of iodine inhibit thyroid hormone synthesis and release. This effect is known as
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