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Question

Which one of the following statements is characteristic of Purpura fulminans ?

The correct answer is
Present as large ecchymosis with irregular shapes.

Purpura Fulminans Characteristics

Purpura fulminans is a critical medical condition characterized by fever, extensive purpura (discoloration due to bleeding under the skin), and signs of disseminated intravascular coagulation (DIC).

Analysis of Options

  • Option 1: Incorrect. While Purpura fulminans involves skin lesions, they are typically hemorrhagic bullae (blisters containing blood) or ecchymoses, not non-hemorrhagic ones.
  • Option 2 (Correct Answer B): Correct. This statement accurately describes the classic presentation of Purpura fulminans. The lesions are indeed large ecchymoses (bruise-like areas) often with irregular shapes and borders, indicating significant blood leakage into the skin.
  • Option 3: Incorrect. Purpura fulminans is frequently triggered by an underlying infection, such as sepsis from bacteria (e.g., Group A Streptococcus). It is not exclusively an autoimmune disorder and is often associated with infections.
  • Option 4: Incorrect. Patients who have had their spleen removed (asplenic) are generally more susceptible to severe infections, including those that can lead to Purpura fulminans. They are not protected; rather, they may be at higher risk.

Key Feature Summary

The defining characteristic of Purpura fulminans among the choices is its presentation as extensive, irregularly shaped ecchymotic skin lesions.

Correct Answer: Option B

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Important Questions from Coagulation Disorders

  1. Which of the following is an oral anticoagulant?
  2. With regard to transfusion therapy, cryoprecipitate is a rich source of which of the following? 

    1. Fibrinogen 

    2. Clotting factor VIII 

    3. Clotting factor IX 

    4. von Willebrand factor 

    Select the correct answer using the code given below.

  3. Which one of the following correctly describes the mode of inheritance of haemophilia B?
  4. Which one of the following is correct regarding blood components in clinical practice ?
  5. Which one of the following drugs causes direct X-a inhibition ?
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