Identify Investigation NOT Appropriate for Recurrent Thrombosis
The question asks to identify the investigation that is generally NOT relevant when evaluating a patient experiencing recurrent thrombosis (repeated blood clots).
Reasoning for Excluding Bcr-Abl Assay
The Bcr-Abl assay detects the Philadelphia chromosome, specific to certain leukemias like CML. While malignancy can increase thrombosis risk, this assay is not a standard test for diagnosing the causes of recurrent blood clots in general.
Relevant Investigations for Recurrent Thrombosis
The following investigations are appropriate for assessing potential causes of recurrent thrombosis:
- Antiphospholipid antibodies: Essential for diagnosing Antiphospholipid Syndrome (APS), a known cause of recurrent clots.
- Protein C and S assays: Evaluate for deficiencies in these natural anticoagulants, which can lead to inherited thrombophilia (a tendency to clot).
- Antithrombin level: Measures antithrombin activity, another key anticoagulant. Low levels indicate a risk for thrombosis.
Therefore, the Bcr-Abl assay is the least appropriate investigation among the options for evaluating recurrent thrombosis, unless specific clinical suspicion for leukemia exists.
Important Questions from Coagulation Disorders
- All of the following are causes of reactive thrombocytosis, EXCEPT:
- Cryoprecipitate cannot be used for treatment of which one of the following conditions?
A young primigravida with 11 weeks pregnancy presents with sudden onset pain and swelling of left lower limb. Homan's sign is positive. Duplex ultrasonogram shows non- compressibility of veins in the affected region, with absent flow. The drug of choice for treatment is:
- Which of the following conditions are associated with prolonged prothrombin time?
1. Factor VIII deficiency
2. Factor VII deficiency
3. Heparin anticoagulation
4. Warfarin anticoagulation
Select the correct answer using the code given below: A female carrier for hemophilia A gene gets married to a genetically normal male. What are the chances of her delivering a male offspring with hemophilia?
