Hormone Receptor Tyrosine Kinase Mechanism
The question asks to identify the hormone that utilizes a receptor tyrosine kinase (RTK) pathway for its cellular action. RTKs are a class of cell surface receptors that possess intrinsic kinase activity. Upon binding of a ligand (hormone or growth factor), the receptor dimerizes and undergoes autophosphorylation, initiating downstream signaling cascades.
Hormone Receptor Analysis
Let's analyze the options provided:
- FSH (Follicle-Stimulating Hormone): Acts via G-protein coupled receptors (GPCRs), specifically the Gs subtype.
- TSH (Thyroid-Stimulating Hormone): Also acts via GPCRs, stimulating the Gs pathway.
- IGF-1 (Insulin-like Growth Factor 1): Binds to the IGF-1 receptor, which is a member of the receptor tyrosine kinase family. Activation leads to autophosphorylation and activation of downstream pathways like PI3K/Akt and MAPK.
- PTH (Parathyroid Hormone): Mediates its effects through GPCRs, primarily activating the Gs pathway, leading to increased cyclic AMP (cAMP).
Conclusion on RTK Action
Based on the receptor types, IGF-1 is the hormone that acts via a receptor tyrosine kinase.
Important Questions from Mechanism Of Disease
- Airway secretions contain all of the following antimicrobial peptides EXCEPT:
- Which of the following is NOT a part of Koch's postulates?
Which of the following are causes of acquired systemic amyloidosis ?
1. Tuberculosis
2. Multiple myeloma
3. Untreated rheumatoid arthritis
4. Chronic osteomyelitis
Select the correct answer using the code given below:
- As per the Gell and Coombs classification, Farmer's lung is which type of hypersensitivity disease ?
- Hormonal regulation of salt and water balance in a nephron occurs at
