Which of the following are causes of acquired systemic amyloidosis ? 1. Tuberculosis 2. Multiple myeloma 3. Untreated rheumatoid arthritis 4. Chronic osteomyelitis Select the correct answer using the code given below:
Acquired Systemic Amyloidosis Causes: Solution
Acquired systemic amyloidosis refers to the deposition of amyloid fibrils in organs, developing after birth due to specific underlying conditions.
Causes of Systemic Amyloidosis
The question asks to identify the causes of acquired systemic amyloidosis from the given list:
- Tuberculosis (1): This chronic infectious disease is a well-known cause of AA amyloidosis, a type of acquired systemic amyloidosis.
- Multiple myeloma (2): This cancer of plasma cells is a primary cause of AL amyloidosis, another form of acquired systemic amyloidosis.
- Untreated rheumatoid arthritis (3): As a chronic inflammatory condition, RA can lead to AA amyloidosis.
- Chronic osteomyelitis (4): This persistent bone infection causes chronic inflammation, which can result in AA amyloidosis.
All four listed conditions are recognized contributors to the development of acquired systemic amyloidosis.
Selecting the Correct Option
Based on the established medical understanding, Tuberculosis, Multiple myeloma, Untreated rheumatoid arthritis, and Chronic osteomyelitis are all causes of acquired systemic amyloidosis.
Therefore, the correct option must include all items 1, 2, 3, and 4.
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