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Question

Which of the following are causes of acquired systemic amyloidosis ? 

1. Tuberculosis 

2. Multiple myeloma 

3. Untreated rheumatoid arthritis 

4. Chronic osteomyelitis 

Select the correct answer using the code given below:

The correct answer is
1, 2, 3 and 4

Acquired Systemic Amyloidosis Causes: Solution

Acquired systemic amyloidosis refers to the deposition of amyloid fibrils in organs, developing after birth due to specific underlying conditions.

Causes of Systemic Amyloidosis

The question asks to identify the causes of acquired systemic amyloidosis from the given list:

  • Tuberculosis (1): This chronic infectious disease is a well-known cause of AA amyloidosis, a type of acquired systemic amyloidosis.
  • Multiple myeloma (2): This cancer of plasma cells is a primary cause of AL amyloidosis, another form of acquired systemic amyloidosis.
  • Untreated rheumatoid arthritis (3): As a chronic inflammatory condition, RA can lead to AA amyloidosis.
  • Chronic osteomyelitis (4): This persistent bone infection causes chronic inflammation, which can result in AA amyloidosis.

All four listed conditions are recognized contributors to the development of acquired systemic amyloidosis.

Selecting the Correct Option

Based on the established medical understanding, Tuberculosis, Multiple myeloma, Untreated rheumatoid arthritis, and Chronic osteomyelitis are all causes of acquired systemic amyloidosis.

Therefore, the correct option must include all items 1, 2, 3, and 4.

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Important Questions from Mechanism Of Disease

  1. As per the Gell and Coombs classification, Farmer's lung is which type of hypersensitivity disease ?
  2. Which one of the following hormones acts via the receptor tyrosine kinase?
  3. Peripheral Eosinophilia is not a characteristic feature of:
  4. \(Na^+\)is reabsorbed in which part/parts of kidney ?
    1. Proximal convoluted tubule
    2. Distal convoluted tubule
    3. Thick ascending limb of loop of Henle
    4. Collecting duct
    Select the correct answer using the code given below:

  5. Consider the following:
    1. Gold
    2. Platinum
    3. Silver
    Which of the above is/are found in e-waste?
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