Which of the following biochemical tests for the detection of aneuploidies is performed in the first trimester of pregnancy?
Biochemical Tests for First Trimester Aneuploidy Screening
Screening for aneuploidies during pregnancy uses specific biochemical markers measured in the mother's blood. The timing of the test determines which markers are relevant.
First Trimester Screening Markers
The standard biochemical tests for aneuploidy detection performed in the first trimester (usually between 11 and 14 weeks) include:
- Pregnancy Associated Plasma Protein A (PAPP-A)
- Free beta-human chorionic gonadotropin (free β-hCG)
Second Trimester Screening Markers
Tests commonly performed in the second trimester (around 15-20 weeks) include:
- Serum alpha-fetoprotein (AFP)
- Unconjugated estriol (uE3)
- Inhibin A
Analysis of Options
Based on the typical usage:
- Serum alpha-feto protein is a second-trimester marker.
- Pregnancy associated plasma protein A is a primary first-trimester marker.
- Unconjugated estriol is a second-trimester marker.
- Inhibin A is primarily used in second-trimester screening.
Therefore, Pregnancy associated plasma protein A is the correct biochemical test for first-trimester aneuploidy detection among the choices provided.
Important Questions from Congenital Disorders
Which of the following is NOT a maternal risk factor for the development of a neural tube defect?
- Trisomy 13 is also known as:
- Which one of the following is a type of glycogen storage disease?
Which of the following is NOT a birth defect related to a disorder in the development of the whole eyeball?
- Which of the following types of tracheoesophageal fistulae is the most common?
