Question
Which of the following are correct regarding Cortisol? 1. Levels are highest in the morning on waking. 2. Cortisol falls dramatically during an illness. 3. More than 95% circulating cortisol is protein bound. 4. It is the major glucocorticoid in humans and can also activate mineralocorticoid receptors. Select the answer using the code given below :
The correct answer is
1, 3 and 4
Cortisol Statement Analysis
Let's evaluate each statement regarding Cortisol:
- Statement 1: Levels are highest in the morning on waking. This statement is correct. Cortisol exhibits a diurnal rhythm, peaking shortly after waking up.
- Statement 2: Cortisol falls dramatically during an illness. This statement is incorrect. Illness or stress typically causes an *increase* in cortisol levels as part of the body's response.
- Statement 3: More than 95% circulating cortisol is protein bound. This statement is correct. Cortisol is largely bound to plasma proteins like transcortin and albumin in circulation.
- Statement 4: It is the major glucocorticoid in humans and can also activate mineralocorticoid receptors. This statement is correct. Cortisol serves as the primary glucocorticoid and possesses some mineralocorticoid activity.
Conclusion
Based on the analysis, statements 1, 3, and 4 are correct. Statement 2 is incorrect.
Therefore, the correct option is the one that includes statements 1, 3, and 4.
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Important Questions from Adrenal Disorders
- Which one of the following is a cause of Secondary Hyperaldosteronism?
- A 50-year lady, who is a known case of rheumatoid arthritis, presents with obesity, moon facies, abdominal striae and hypertension. Overnight dexamethasone suppression test shows serum cortisol is greater than 50 nmol/L, serum ACTH is less than 1.1 pmol/L. The adrenal imaging and brain CT/MRI imaging studies are unremarkable. The likely diagnosis is
- Hirsutism is seen in which of the following ?
1. Polycystic ovarian syndrome
2. Congenital adrenal hyperplasia
3. Hypothyroidism
4. Ovarian tumour
Select the correct answer using the code given below: - A patient presents with circulatory shock, nausea, vomiting and diarrhoea. A diagnosis of acute adrenal crisis is considered. A blood sample is stored for measurement of serum cortisol and treatment started without delay. Which of the following are appropriate interventions?
1. IV normal saline
2. IV hydrocortisone 100 mg stat
3. IV 10% glucose
4. IV KCl as infusion
Select the correct answer using the code given below: - Escape behaviour with paroxysmal occurrence is seen in:
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