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Question

The most common acid-base disturbance in critically ill patients is :

The correct answer is
Chronic respiratory alkalosis

Critically Ill Patients Acid-Base Disturbance

Understanding acid-base disturbances is crucial in critical care settings.

Common Acid-Base Imbalance

In critically ill patients, the most frequently observed acid-base disturbance is chronic respiratory alkalosis.

Physiological Basis

  • Critically ill patients often experience conditions leading to increased respiratory drive or altered ventilation mechanics.
  • Factors such as sepsis, pain, anxiety, mechanical ventilation settings, and certain medications can cause hyperventilation (breathing faster or deeper than necessary).
  • Hyperventilation leads to excessive elimination of carbon dioxide (CO2) from the blood.
  • According to the relationship between CO2 and pH, a decrease in CO2 (hypocapnia) results in an increase in blood pH, causing an alkalosis.
  • When this state persists over time, it is classified as chronic respiratory alkalosis.

While other acid-base disturbances can occur, the prevalence of factors causing hyperventilation makes chronic respiratory alkalosis the most common in this patient population.

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Important Questions from Acid-Base Disorders

  1. In a child with high anion gap metabolic acidosis, poisoning with which of the following may be suspected ?
  2. Following are the causes of high anion-gap acidosis except:
  3. Salicylate intoxication in adults usually causes:
    1. Severe respiratory alkalosis.
    2. Mixed metabolic acidosis respiratory alkalosis.
    3. Hyperchloremic metabolic acidosis.
    Select the correct answer using the code given below
  4. Which one of the following pairs is not correctly matched?
  5. Consider the following:
    1. Normal anion gap
    2. Hyperchloraemic acidosis
    3. Inappropriately high urinary pH (>5.4)
    Which of the above are the characteristic features of renal tubular acidosis (RTA)?

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