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Question

The following are the myeloproliferative disorders except :

The correct answer is
Hairy cell leukaemia

Myeloproliferative Disorders Classification

Myeloproliferative disorders (MPNs) are a group of conditions characterized by the overproduction of one or more types of mature blood cells (red blood cells, white blood cells, or platelets) stemming from a clonal expansion of hematopoietic stem cells in the bone marrow.

Evaluating the given options:

  • Polycythemia vera: Characterized by the overproduction of red blood cells. This is a classic MPN.
  • Essential thrombocytosis: Characterized by the overproduction of platelets. This is also a classic MPN.
  • Chronic myeloid leukaemia (CML): Characterized by the overproduction of granulocytes (a type of white blood cell). CML is a well-defined MPN.
  • Hairy cell leukaemia: This is a distinct type of chronic B-cell lymphoproliferative disorder. It arises from lymphoid cells, not myeloid precursors, and is therefore not classified as an MPN.

Hairy cell leukaemia is the condition listed that is not a myeloproliferative disorder.

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Important Questions from Leukemia

  1. The Rai staging system and Binet staging system are the two widely used staging systems used for staging which of the following hematological malignancies?
  2. The BCR-ABL1 oncoprotein exhibits constitutive activity of which one of the following enzymes?
  3. Imatinib, Dasatinib, Nilotinib and Ponatinib are examples of which class of drugs?
  4. Which one of the following is a clonal haematopoietic stem cell disorder in which phenotypically normal red blood cells, granulocytes and platelets accumulate in the absence of a recognizable physiological stimulus?
  5. Which one of the following combinations of drugs can be used for treatment of relapsed myeloma ?
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