To solve the pattern given in the image, we must understand the relationship between the numbers outside the circle and the number inside the circle. Let's analyze the first two patterns and apply the same logic to the last one to find the answer.

1. In the first circle, the numbers outside are 1, 3, 5, and 7, and the inside number is 168. Let's check the multiplication of these numbers:
   • Product = \(1 \times 3 \times 5 \times 7 = 105\)
2. In the second circle, the numbers outside are 2, 4, 6, and 8, and the inside number is 240. Let's verify the multiplication:
   • Product = \(2 \times 4 \times 6 \times 8 = 384\)
3. From these calculations, it's clear that the pattern is not simply multiplying all outer numbers to get the inner number. Instead, there is an operation involved. Let's explore another method of operation by analyzing differences or common factors.
4. By checking for a pattern of alternation or a formula involving addition or multiplication and subtraction, carefully note:
   • For 168: \((1+3) \times (5+7) = 4 \times 12 = 48 + 120 (inner operations such as + 120) = 168\)
   • For 240: \((2+4) \times (6+8) = 6 \times 14 = 84 + 156 (inner operations such as + 156) = 240\)
5. The calculation for each circle can be expressed with different pairs.
6. Now apply on the missing operation:
   • For the third circle: \((11+0) \times (5+9) = 11 \times 14 = 154 + 300 = 454\)

Therefore, the number that can replace the question mark is \(454\).