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Question

Select the incorrect statements with reference to Rh grouping.
A. Erythroblastosis foetalis is a condition observed having fetus with Rh$^{-ve}$ blood and mother with Rh$^{+ve}$ blood.
B. Rh antigen is observed on RBCs in the majority of human beings.
C. Before blood transfusion, Rh group should also be matched.
D. Rh incompatibility is observed when a pregnant mother is Rh$^{-ve}$ and the fetus is Rh$^{+ve}$.
E. Erythroblastosis foetalis can be avoided by administering anti-Rh antibodies to the mother immediately after the delivery of the second child.
Choose the answer from the options given below :

This question was previously asked in
NEET UG Re-Exam 2026 Question Paper (21-Jun-2026)
The correct answer is
A and E only

Rh Grouping Statements Analysis

This analysis identifies incorrect statements regarding Rh grouping, focusing on Erythroblastosis foetalis and blood transfusion compatibility.

Analyzing Rh Incompatibility Statement A

Statement A: Erythroblastosis foetalis is a condition observed having fetus with Rh$^{-ve}$ blood and mother with Rh$^{+ve}$ blood.

Reasoning: This is incorrect. The condition, Hemolytic Disease of the Newborn/Fetus, specifically occurs when an Rh$^{-ve}$ mother carries an Rh$^{+ve}$ fetus. Maternal Rh$^{+ve}$ blood and fetal Rh$^{-ve}$ blood do not cause this condition.

Analyzing Rh Antigen Statement B

Statement B: Rh antigen is observed on RBCs in the majority of human beings.

Reasoning: This is correct. Approximately 85% of the human population is Rh$^{+ve}$, meaning they possess the Rh antigen on their red blood cells.

Analyzing Rh Transfusion Statement C

Statement C: Before blood transfusion, Rh group should also be matched.

Reasoning: This is correct. Rh factor compatibility is crucial during blood transfusions to prevent immune responses and potential transfusion reactions, especially for individuals who may become sensitized.

Analyzing Rh Incompatibility Statement D

Statement D: Rh incompatibility is observed when a pregnant mother is Rh$^{-ve}$ and the fetus is Rh$^{+ve}$.

Reasoning: This is correct. This specific scenario defines Rh incompatibility during pregnancy, which can lead to complications like Erythroblastosis foetalis.

Analyzing Rh Prevention Statement E

Statement E: Erythroblastosis foetalis can be avoided by administering anti-Rh antibodies to the mother immediately after the delivery of the second child.

Reasoning: This is incorrect. Effective prevention involves administering anti-Rh antibodies (e.g., RhoGAM) to Rh$^{-ve}$ mothers during pregnancy (around 28 weeks) and within 72 hours after delivering an Rh$^{+ve}$ baby. This prevents the mother from developing her own antibodies (sensitization). The statement's timing ("after the second child") is inaccurate and incomplete for preventing initial sensitization.

Conclusion on Incorrect Rh Statements

The analysis confirms that statements A and E are factually incorrect regarding Rh grouping principles and clinical applications.

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