Question
Regarding rheumatoid arthritis, the following statements are true except
The correct answer is
Subcutaneous nodules are more frequent in seronegative patients
Rheumatoid Arthritis: Analyzing Statements
The question asks to identify the statement that is NOT true regarding rheumatoid arthritis (RA). Let's analyze each option:
-
Option 1: The cricoarytenoid joint may be involved
Rheumatoid arthritis is known to affect various joints, including less common ones like the cricoarytenoid joint in the larynx. Involvement here can lead to hoarseness. Thus, this statement is considered true for RA. -
Option 2: HLA-D4 and HLA-DR4 are positive in patients with seropositive rheumatoid arthritis
Specific human leukocyte antigen (HLA) alleles, particularly subtypes of HLA-DRB1 like HLA-DR4 (often written as HLA-D4 or HLA-DR4), are strongly associated with an increased risk and severity of rheumatoid arthritis, especially in seropositive individuals (those with rheumatoid factor or anti-CCP antibodies). This statement is true. -
Option 3: Subcutaneous nodules are more frequent in seronegative patients
Subcutaneous rheumatoid nodules are characteristic extra-articular manifestations of RA. However, these nodules are typically found more often in patients who are seropositive (RF-positive or anti-CCP positive) rather than seronegative. Therefore, this statement is false. -
Option 4: Diffuse intestinal fibrosis and pneumonitis may occur
Rheumatoid arthritis is a systemic disease that can affect organs beyond the joints. Lung involvement, such as interstitial lung disease and pneumonitis, is a well-documented extra-articular manifestation. While diffuse intestinal fibrosis is less common, the potential for systemic and pulmonary involvement makes this statement plausible and generally considered true in the context of RA's systemic nature.
Conclusion on Rheumatoid Arthritis Statements
Based on the analysis, the statement that is factually incorrect regarding rheumatoid arthritis is that subcutaneous nodules are more frequent in seronegative patients. These nodules are more commonly associated with seropositive RA.
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Important Questions from Arthritis
- Which of the following statements regarding Ankylosing spondylitis (AS) are true?
1. AS occurs in about 10 % of Inflammatory Bowel Disease(IBD) patients
2. The AS activity is related to Bowel activity in IBD patients
3. The AS activity does remit with glucocorticoids or colectomy in IBD patients
Select the correct answer using the code given below: - Which of the following statements about “Early onset Osteoarthritis” are true?
1. Onset is usually before the age of 55 years
2. There is clear history of previous trauma
3. In most cases, single joint is affected
Select the correct answer using the code given below: - A 31-year young man presents with fever, weight loss, pain with swelling of knee joint and low backache with stiffness. Three weeks earlier, he was treated for symptoms of urinary tract infection by local practitioner. The joint aspirate is leucocyte rich and contains multinucleated macrophages. His urine culture is sterile. What is the most probable diagnosis?
- Consider the following statements regarding Gout in old age.
1. Most of older patients have gout secondary to diuretic use and chronic kidney disease
2. Joints of the upper limbs are more frequently affected
3. Presentation is typical with acute attack of gout
Which of the statements given above are correct? - A 28-year old woman complains of arthritis involving bilateral metacarpophalangeal, proximal interphalangeal and wrist joints of one year duration. The most likely disease entity is:
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