Column-I Column-II P. Autosomal recessive inheritance 1. Huntington disease Q. Autosomal dominant inheritance 2. Hairy ears R. X-linked inheritance 3. Cystic fibrosis S. Y-linked inheritance 4. Hemophilia
Matching Chromosomal Inheritance Patterns
This question requires matching different types of chromosomal inheritance patterns (Column-I) with their corresponding genetic diseases or traits (Column-II).
Understanding Inheritance Patterns and Diseases
P. Autosomal Recessive Inheritance
This occurs when a disease is caused by two copies of an altered gene, one inherited from each parent. Cystic fibrosis is a classic example of an autosomal recessive disorder.
Correct Match: P - 3. Cystic fibrosis
Q. Autosomal Dominant Inheritance
In this pattern, only one copy of the altered gene is needed to cause the condition. Huntington disease is an example of an autosomal dominant disorder.
Correct Match: Q - 1. Huntington disease
R. X-linked Inheritance
These genetic traits are located on the X chromosome. Since males have only one X chromosome, they are often more affected by X-linked recessive disorders. Hemophilia is a well-known X-linked recessive disease.
Correct Match: R - 4. Hemophilia
S. Y-linked Inheritance
This type of inheritance is linked to the Y chromosome and affects only males, being passed down from father to son. The trait of hairy ears (hypertrichosis pinnae) is commonly used as an example of Y-linked inheritance.
Correct Match: S - 2. Hairy ears
Summary of Matches
| Inheritance Type (Column-I) | Disease/Trait (Column-II) | Match |
|---|---|---|
| P. Autosomal recessive | 3. Cystic fibrosis | P-3 |
| Q. Autosomal dominant | 1. Huntington disease | Q-1 |
| R. X-linked | 4. Hemophilia | R-4 |
| S. Y-linked | 2. Hairy ears | S-2 |
The correct combination matching Column-I to Column-II is P-3, Q-1, R-4, S-2.
Important Questions from Mendelian Inheritance
- Mendel's 'law of segregation' applies to the segregation of __________ during gamete formation.
- Fabry disease in humans is a X-linked disease. The probability (in percentage) for a phenotypically normal father and a carrier mother to have a son with Fabry disease is ________.
The allele associated with albinism in humans is recessive ($c$). The probability that an albino male ($cc$) and a carrier female ($Cc$) will have an offspring with normal skin pigmentation is _________.
(Round off to one decimal place)
- The blood group of the mother is A⁺ and that of the father is AB⁺. Which of the following statements is/are correct?
- Assuming independent assortment and no recombination, the number of different combinations of maternal and paternal chromosomes in gametes of an organism with a diploid number of 12 is ________.
