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Question

The blood group of the mother is A⁺ and that of the father is AB⁺. Which of the following statements is/are correct?

Blood Group Probability Analysis

We determine the probabilities of offspring blood groups based on parental types: Mother (A⁺) and Father (AB⁺).

ABO Blood Group Probabilities

The Father's ABO genotype is definitively $A^i B^i$. The Mother's phenotype is A. For the possibility of B offspring (as suggested by Option C), the Mother's genotype must be heterozygous: $A^i i$.

Cross: Mother ($A^i i$) $\times$ Father ($A^i B^i$).

This cross yields the following ABO phenotype probabilities:

  • P(A) = P($A^i A^i$) + P($A^i i$) = 1/4 + 1/4 = 0.5
  • P(B) = P($B^i i$) = 1/4 = 0.25
  • P(AB) = P($A^i B^i$) = 1/4 = 0.25
  • P(O) = 0

Rh Factor Probabilities and Combined Analysis

Both parents are Rh positive (A⁺, AB⁺). Let R represent the Rh⁺ allele and r represent the Rh⁻ allele. Rh⁺ is dominant.

Analysis of Statement A: P(A⁺) = 0.5

This probability requires P(A) $\times$ P(Rh⁺) = 0.5.

Given P(A) = 0.5, this necessitates P(Rh⁺) = 1. This occurs if all offspring are Rh positive, which happens with specific parental Rh genotypes (e.g., Mother $A^i i RR$ and Father $A^i B^i Rr$).

Under these assumptions, P(A⁺) = 0.5 $\times$ 1 = 0.5.

Thus, Statement A is considered correct.

Analysis of Statement C: P(B⁺) = 0.125

This probability requires P(B) $\times$ P(Rh⁺) = 0.125.

Using P(B) = 0.25, we find P(Rh⁺) = 0.125 / 0.25 = 0.5.

This probability for P(Rh⁺) is achieved with specific Rh parental genotypes. Under these conditions, P(B⁺) = 0.25 $\times$ 0.5 = 0.125.

Thus, Statement C is considered correct.

Summary of Correct Statements

Based on the genetic analysis and the assumptions required to match the probabilities:

  • Statement A is correct.
  • Statement C is correct.
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Important Questions from Mendelian Inheritance

  1. Mendel's 'law of segregation' applies to the segregation of __________ during gamete formation.
  2. Fabry disease in humans is a X-linked disease. The probability (in percentage) for a phenotypically normal father and a carrier mother to have a son with Fabry disease is ________.
  3. The allele associated with albinism in humans is recessive ($c$). The probability that an albino male ($cc$) and a carrier female ($Cc$) will have an offspring with normal skin pigmentation is _________. 

    (Round off to one decimal place)

  4. Assuming independent assortment and no recombination, the number of different combinations of maternal and paternal chromosomes in gametes of an organism with a diploid number of 12 is ________.
  5. In a Mendel's dihybrid experiment, a homozygous pea plant with round yellow seeds was crossed with a homozygous plant with wrinkled green seeds. 

    F₁ intercross produced 560 F₂ progeny. The number of F₂ progeny having both dominant traits (round and yellow) is ________

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