Choose the correct match of rate limiting step in absorption of given drugs.LIST-I
Rate limiting stepLIST-II
DrugsA. Gastric emptying time I. Insulin B. Dissolution II. Diltiazem C. Permeability III. Taxol D. Case by case IV. Nifedipine
Choose the correct answer from the options given below:
Drug Absorption Rate Limiting Steps Matching
Identifying Rate-Limiting Steps for Drug Absorption
This question requires matching specific drugs with their primary rate-limiting step during oral absorption based on their physicochemical properties and pharmacokinetic behavior.
Correct Pairings Explained:
- A. Gastric emptying time: This step determines how quickly a drug moves from the stomach to the small intestine. It's relevant for drugs like II. Diltiazem, whose absorption primarily occurs in the intestine.
- B. Dissolution: The process by which a solid drug dissolves into solution. This is often rate-limiting for drugs with poor water solubility, such as IV. Nifedipine.
- C. Permeability: Refers to the drug's ability to pass through biological membranes. For large molecules like peptides, such as I. Insulin, poor permeability is a major barrier to oral absorption.
- D. Case by case: This indicates that the absorption rate is variable and depends on multiple factors, including formulation and physiological conditions. This label fits complex drugs like III. Taxol.
Therefore, the correct match is A-II, B-IV, C-I, and D-III.
Similar Questions
- Given below are two statements: one is labelled as Assertion A and the other is labelled as Reason R
Assertion A: The small engraved area in letter like 'A', 'B' and 'O' are difficult to tablet manufacture cleanly
Reason R: Because tablet punches having engraving exhibit picking problem in compression.
In the light of the above statements, choose the most appropriate answer from the options given below - Given below are two statements: one is labelled as Assertion A and the other is labelled as Reason R
Assertion A: At high electrolyte concentration, dispersed systems becomes coagulated
Reason R: Repulsive forces among particles are greatly reduced.
In the light of the above statements, choose the most appropriate answer from the options given below - Sequence the parts of metering valve in aerosol package in proper order
A. Outlet valve seal
B. Capillary dip tube
C. Inlet valve seal
D. Two piece stainless steel stem
Choose the correct answer from the options given below: - The proper sequence of phenomenon in percutaneous absorption via trans follicular route is:
A. Partitioning into sebaceous gland
B. Diffusion through viable epidermis
C. Partitioning into viable epidermis
D. Diffusion through upper dermis
Choose the correct answer from the options given below: - Find the correct order of unit process in tablet compression:
A. Compression
B. Screening
C. Mixing of diluent and disintegrant
D. Slugging
Choose the correct answer from the options given below: - Choose the correct combination of excipients and their toxicity
A. Talc : Lung tumor in female rats
B. Limonene: Hyaline droplet formation
C. Tartrazine: Cardiac toxicity
D. Menthol: Deramatitis
Choose the correct answer from the options given below: - Choose the correct excipeints and choice considerations:
A. Sodium cyclamate: Non carcinogenicity
B. Aspartame: Stable in solution
C. Fructose : Rapid onset of apparant sweetness
D. Saccharine : Unpleasant after taste
Choose the correct answer from the options given below: - Select the correct pair of globulins and drug with which they show binding:
A. Gama globulin: Specific antigens
B. Ceruloplasmin: Vitamin D
C. Transferin: Ferrous ions
D. Beta 2 globulin: Cortisone
Choose the correct answer from the options given below: - Match the LIST-I with LIST-II
LIST-I
(Drug Combination)LIST-II
(Interaction)A. Penicillamine: Aluminum containing antacids I. Decreased plasma level B. Lithium carbonate: Atropine II. Delayed gastric emptying C. Oral contraceptives: Ampicillin III. Formulation of poorly soluble complex D. Amitriptyline: Phenobarbitone IV. Decreased reabsorption of drug
Choose the correct answer from the options given below: - Match List I with List II: Match the Aq. Solubility with the drugs with melting points
LIST-I
(Aqueous solubility (moles/ liter x 102)in water at 30°C))LIST-II
(Drugs with melting points in °C)A. 4.5 I. 7-Propyl theophylline (99-100) B. 13.3 II. Caffeine (238) C. 17.6 III. Theophylline (270-274) D. 104 IV. 7-Ethyl theophylline (156-157)
Choose the correct answer from the options given below:
Important Questions from Mixed Topic (CUET PG)
- Who was the founder of Bolshevik Communist party?
- What is the key guide to statecraft in the realist tradition?
- Chronologically arrange the events in the Cold War period.
A. Berlin Wall is constructed
B. Communist China joins the UN
C. Soviet invasion of Czechoslovakia
D. Berlin Blockade
Choose the correct answer from the options given below: Morgenthau's principles of political realism are:
A. Politics is rooted in permanent and unchanging human nature which is basically self centred, self-regarding and self-interested
B. Politics is an autonomous sphere of action and cannot therefore be reduced to morals
C. International Politics is an arena of conflicting self-interests
D. The ethics of international relations is situational ethics which is very different from private morality
Choose the correct answer from the options given below:Who among the following political thinkers consider the anarchical self help system to be a compelling factor for States to maximise their relative power positions?
