Match the antibiotics in Group I with their modes of action in Group II. Group I Group II P) Chloramphenicol 1) Inhibits protein synthesis by acting on 30S ribosomal subunit Q) Rifampicin 2) Interferes with DNA replication by inhibiting DNA gyrase R) Tetracycline 3) Inhibits protein synthesis by acting on 50S ribosomal subunit S) Quinolone 4) Interferes with RNA polymerase activity 5) Inhibits $\beta$-lactamase activity
Antibiotic Group Matching
The question requires matching antibiotics from Group I with their respective modes of action from Group II.
Matching Group I to Group II
Let's match each antibiotic with its correct mode of action:
- P) Chloramphenicol: This antibiotic inhibits bacterial protein synthesis by binding reversibly to the 50S ribosomal subunit. This corresponds to item 3 in Group II.
- Q) Rifampicin: This antibiotic inhibits DNA-dependent RNA polymerase activity in bacteria, thus interfering with RNA synthesis. This corresponds to item 4 in Group II.
- R) Tetracycline: This antibiotic inhibits protein synthesis by binding to the 30S ribosomal subunit, preventing tRNA attachment. This corresponds to item 1 in Group II.
- S) Quinolone: This class of antibiotics, such as nalidixic acid and fluoroquinolones, interferes with bacterial DNA replication by inhibiting DNA gyrase (topoisomerase II) and topoisomerase IV. This corresponds to item 2 in Group II.
Correct Matches
Based on the analysis, the correct pairings are:
- P - 3
- Q - 4
- R - 1
- S - 2
This corresponds to option 2 (P-3, Q-4, R-1, S-2).
Important Questions from Antibiotics and Antimicrobial Resistance
- Which one of the following antibiotics blocks protein chain elongation by preventing the action of peptidyl transferase ?
- Which of the following statement(s) is(are) TRUE about fluoroquinolone drugs?
- A list of pathogens (Group I) and a list of anti-microbial agents (Group II) used to treat their infections are given below. Match the pathogens with the corresponding anti-microbial agents.
Group I Group II [P] Influenza A virus 1. Isoniazid [Q] Fungus 2. Amantadine [R] Plasmodium 3. Fluconazole [S] Mycobacterium 4. Artemisinin 5. Iodoquinol A bacterial culture (200 µl containing $1.8 \times 10^9$ cells) was treated with an antibiotic Z (50 µg per ml) for 4 h at 37°C. After this treatment, the culture was divided into two equal aliquots.
Set A: 100 µl was plated on Luria agar.
Set B: 100 µl was centrifuged, the cell pellet washed and plated on Luria agar.
After incubating these two plates for 24 h at 37°C, Set A plate showed no colonies, whereas the Set B plate showed $0.9 \times 10^9$ cells. This experiment showed that the antibiotic Z is
- Which of the following antimicrobial agent(s) is/are growth factor analog(s)?
